Gastrointestinal Symptoms of Food Challenge-proven Non-IgE Cow's Milk Allergy Are Dissipated by Early School Age.

Objectives: The aim of this study was to evaluate the current well-being and dietary restrictions in children 6 years after food challenge-confirmed diagnosis of non-IgE cow's milk protein allergy, compared to peers with gastrointestinal symptoms but negative food challenge. This study aimed to evaluate the diagnostic process retrospectively.

Methods: This is an Internet-based survey for mothers whose children underwent 6 years ago the double-blind, placebo-controlled food challenge for cow's milk (CM) because of gastrointestinal symptoms causing suspicion of non-IgE CM protein allergy.

Blood pressure profiles 5 to 10 years after transplant in pediatric solid organ recipients.

Arterial hypertension is a major risk factor for cardiovascular disease after solid organ transplantation, emphasizing the need for blood pressure (BP) monitoring. The authors studied 24-hour ambulatory BP monitoring (ABPM) parameters (index, load, dipping) and their predictive value with regard to hypertension as well as correlations with graft function and metabolic parameters such as obesity and dyslipidemias. The ABPM profiles of 111 renal, 29 heart, and 13 liver transplant recipients were retrospectively analyzed 5 to 10 years after transplant (median 5.

Diagnosis and treatment of bronchiolitis in Finnish and Swedish children's hospitals.

Aim: There is no widely accepted consensus on the diagnosis and treatment of bronchiolitis. This study describes current practices in Finnish and Swedish hospitals.

Methods: A questionnaire on the diagnosis and treatment of bronchiolitis in children below 2 years of age was sent to all Finnish and Swedish hospitals providing inpatient care for children.

Metabolic risk factors and long-term graft function after paediatric renal transplantation.

The aim of this study was to evaluate metabolic risk factors and their impact on long-term allograft function in paediatric renal transplant (RTx) patients. We reviewed the medical records of 210 RTx patients who underwent transplantation at a median age of 4.5 years (range 0.

A time-to-event model for acute rejections in paediatric renal transplant recipients treated with ciclosporin A.

Aims: Ciclosporin A (CsA) dosing in immunosuppression after paediatric kidney transplantation remains challenging, and appropriate target CsA exposures (AUCs) are controversial. This study aimed to develop a time-to-first-acute rejection (AR) model and to explore predictive factors for therapy outcome.

Methods: Patient records at the Children's Hospital in Helsinki, Finland, were analysed.

Risk factors for impaired quality of life and psychosocial adjustment after pediatric heart, kidney, and liver transplantation.

Few studies compare HRQOL and PSA in children who have undergone different types of solid organ Tx. In this cross-sectional study, HRQOL and PSA were assessed in 74 Tx patients (16 heart, 44 kidney, 14 liver) at a mean age of 11.5 (range 6.

[Evaluation of training of pediatric specialists].

Regular audit of training of specialist physicians by means of comparable methods is a recommended means to take care of immediate quality assessment of the training. An audit group consisting of the professor of pediatrics at the University of Helsinki and professor of pediatrics at the University of Tampere, two clinical lecturers and two representatives of physicians specializing in pediatrics at the Children's Hospital together with an outside expert evaluates the common trunk belonging to specialization in pediatrics in teaching hospitals. The group stated that the recommendation for degree associated with specialist training is being followed in the hospitals, but the follow-up of the objectives and their implementation is insufficient.

Outcome of pediatric heart transplantation recipients treated with ventricular assist device.

This study was conducted to evaluate the long-term prognosis of pediatric HTx patients treated with VAD before transplantation. The clinical data of six patients bridged to HTx with Berlin Heart EXCOR pediatric device were analyzed retrospectively. Information about graft function, CA results, and EMB findings as well as appearance DSA was collected.

Neuropsychological profile of children with kidney transplants.

Background: Varying results on the cognitive outcome of children who have undergone kidney transplantation (KTx) have raised concern for specific neurocognitive difficulties.

Methods: Fifty children with KTx were assessed at a mean age of 11.1 (SD 3.

Quality of life in adult survivors of pediatric kidney transplantation.

Background: There are few studies assessing long-term adult outcome and health-related quality of life (HRQOL) in former pediatric high-risk kidney transplant (TX) recipients.

Methods: Twenty-one patients were assessed at mean age of 21.1 years.

Donor-specific HLA antibodies and graft function in children after renal transplantation.

Background: The presence of circulating donor-specific human leukocyte antigen antibodies (HLA-DSA) has been associated with chronic antibody-mediated rejection, leading to progressive graft dysfunction and poor graft survival.The aim of this study was to investigate the incidence and significance of HLA-DSA in paediatric renal transplantation(RTx) patients.

Methods: A total of 294 post-transplant serum samples from 123 RTx patients were retrospectively analysed for HLA antibodies.

Pubertal development is normal in adolescents after renal transplantation in childhood.

Background: This study was conducted to evaluate the pubertal development in adolescents after renal transplantation (RTx) in childhood.

Methods: We performed a retrospective review of medical records of 109 RTx recipients (72 males) transplanted at the median age of 4.5 years (range: 0.

Visuospatial impairment in children and adolescents after liver transplantation.

A minority of children with liver transplants exhibit significant delay in global intelligence; others have specific learning disabilities. More specific data on neurocognitive strengths and weaknesses are lacking. Eighteen children aged 7-16 yr, who had undergone LTx in Finland participated in the study.

Neurocognitive function of pediatric heart transplant recipients.

Background: Pediatric heart transplant recipients exhibit cognitive delays, as evident in assessments of their general intelligence. Less is known about their specific neurocognitive impairments.

Methods: All 19 children in Finland aged 6 to 16 years who had undergone heart transplantation (HTx) participated.

[An infant less than three months of age at emergency call service].

Examination and treatment of an infant less than three months of age requires different action at the emergency department as compared with bigger children. Even slight cough and vomiting may be indications of a severe disease in this age group. In addition, symptoms in small infants are often diffuse and sometimes difficult to observe and analyze.

Headache in children and adolescents after organ transplantation.

The prevalence and characteristics of headache were studied in a national cohort of 177 pediatric patients with kidney, liver, and heart transplants. All patients received triple drug immunosuppression with CsA, Aza, and MP. Data on headaches were collected by sending two questionnaires and reviewing the medical records.

Early treatment of acute rejections gives favorable long-term function after renal transplantation in small children.

AR is considered as a risk factor for CAN after kidney TX. We combined data on AR with long-term graft function and histopathology to assess whether early treatment of AR is beneficial for long-term graft outcome in small children. Seventy-seven children with a mean age of 4.

Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1).

Background: Recurrent nephrotic syndrome (NS) is a severe problem after renal transplantation in patients with congenital nephrotic syndrome of the Finnish type (NPHS1). The NPHS1 kidneys do not express nephrin, and antibodies against this major glomerular filter protein have been observed in NPHS1 children with recurrent NS. We evaluated here the use of plasma exchange (PE) therapy and kidney retransplantation in NPHS1 patients with recurrent NS and extended our studies on the pathogenesis of the recurrence.

Muscular dystonia and athetosis in six patients with congenital nephrotic syndrome of the Finnish type (NPHS1).

Congenital nephrotic syndrome of the Finnish type (NPHS1, CNF) is an autosomal recessively inherited disease occurring due to mutations in the nephrin gene (NPHS1). Two main Finnish mutations exist: Fin-major and minor, which both cause a lack of nephrin and absence of the slit diaphragm between the podocytes. This leads to severe proteinuria, nephrotic syndrome and infections, and without dialysis or renal transplantation, death in infancy.

Psychosocial adjustment and quality of life after renal transplantation in early childhood.

Psychosocial adjustment and quality of life has been reported good in children after a successful renal transplantation (Tx). There are, however, few reports of using standardized methods in evaluating these issues, particularly in small children. We investigated the psychosocial adjustment in 32 children at school age (mean 9.

Neuroradiologic findings in children with renal transplantation under 5 years of age.

Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known.

Psychosocial adaptation after solid organ transplantation in children.

The possibility of extending life with advanced medical procedures such as organ transplantation in childhood has made it possible to focus on patients' well-being in a wider perspective. They still experience a high prevalence of medical and physical disabilities, which definitively have an impact on a child's psychosocial adjustment after transplantation. Many disabilities originate before transplantation, and much effort should be taken to diminish possible complications and ameliorate growth and neurodevelopment, which have an impact for later adjustment regardless of a successful transplantation.

Growth after renal transplantation in infancy or early childhood.

Forty-one children <5 years of age at kidney transplantation (TX) were investigated for growth, bone age, and renal function up to 7 years ( n=26) after TX. All children received triple immunosuppression, including alternate-day corticosteroid treatment. Catch-up growth was seen in 81% of 30 children without growth hormone (GH) treatment.

Neurodevelopmental outcome in high-risk patients after renal transplantation in early childhood.

Patient and graft survival rates of pediatric renal transplant recipients are currently excellent, but there are few reports regarding the long-term neurodevelopmental outcome after renal transplantation (Tx) in early childhood. Children with renal failure from infancy would be expected to have a less favorable developmental prognosis. We report the neurodevelopmental outcome in 33 school-age children transplanted between 1987 and 1995 when < 5 yr of age.