Publications by authors named "Erik J Offerman"
Background: Genomewide association studies have associated >100 genetic loci with atrial fibrillation (AF), but establishing causal genes contributing to AF remains challenging.
Objective: The purpose of this study was to determine candidate novel causal genes and mechanistic pathways associated with AF risk loci by incorporating gene expression and coexpression analyses and to provide a resource for functional studies and targeting of AF-associated genes.
Methods: Cis-expression quantitative trait loci were identified for candidate genes near AF risk variants in human left atrial tissues.
Myocardial injury after non-cardiac surgery (MINS) is common. We investigated the incidence and outcomes of MINS, and mechanistic underpinnings using pre-operative whole blood gene expression profiling in a prospective cohort study of individuals undergoing lower extremity revascularization (LER) for peripheral artery disease (PAD). Major adverse cardiovascular and limb events (MACLE) were defined as a composite of death, myocardial infarction, stroke, major lower extremity amputation or reoperation.
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- - The text discusses a new technique for nonenhanced magnetic resonance angiography (MRA) that eliminates the need for traditional electrocardiographic gating, which is often affected by external interferences during imaging.
- - Instead, the new method uses a self-gating approach that detects blood flow acceleration during heart contractions, achieving 99% accuracy in imaging the peripheral arteries of eight healthy subjects.
- - The study found that the self-gated technique produced similar image quality and contrast to the electrocardiographic method, while the pulse gating method showed lower quality results.
Purpose: To evaluate the signal properties of 2D time of flight (TOF), quiescent-interval single-shot (QISS), ECG-gated 3D fast spin-echo (FBI), and ungated 3D fast spin-echo ghost (Ghost) magnetic resonance angiography (MRA) over a range of flow velocities in a pulsatile flow phantom with a 50% diameter stenosis at 1.5T.
Materials And Methods: Blood-mimicking fluid was pumped at eight peak flow velocities through a stenotic region in triphasic and monophasic waveforms.