Publications by authors named "Erik J Kopping"
Article Synopsis
- The text discusses the Gram-negative bacteria that cause tularemia, highlighting its virulence and ability to evade the host's immune system.
- It focuses on the outer membrane channel (OMC) protein TolC, which is crucial for suppressing immune responses during macrophage infections and also plays a role in drug resistance.
- The study found that while multiple OMCs help with drug resistance, only TolC is key for preventing macrophage cell death, and noted that the type of cell death during infections varies between different bacterial strains.
Article Synopsis
- A study focused on 13 patients with advanced HIV (CD4 count under 200 cells/μL) who also had severe mpox and multiple organ issues.* -
- These patients underwent long treatments with various medications, including tecovirimat and others, but still faced serious health complications.* -
- The outcomes showed that they had long hospital stays and a high death rate, highlighting the severity of their conditions.*
Article Synopsis
- The study conducted a serosurvey in NYC during the peak of the 2022 mpox outbreak to understand the undetected prevalence of infections among asymptomatic individuals without prior vaccination.
- Out of 419 participants, around 6.4% showed seropositivity for mpox, with higher rates among men who have sex with men (MSM) compared to ciswomen.
- The findings suggest that there were significant asymptomatic infections present, which could continue to influence the spread of mpox.
is a zoonotic pathogen and the causative agent of tularemia. replicates to high levels within the cytosol of macrophages and other host cells while subverting the host response to infection. Critical to the success of is its ability to delay macrophage apoptosis to maintain its intracellular replicative niche.
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- The study investigates the role of the outer membrane protein TolC and its orthologs FtlC and SilC in the virulence of the pathogen responsible for tularemia, highlighting their involvement in multidrug efflux and immune response modulation.
- It was found that TolC is crucial for altering macrophage responses during infection, while FtlC also plays a significant role in virulence, specifically through the intradermal infection route.
- Overall, the research indicates that while TolC is essential for immune response modulation and virulence in a general sense, the contributions of each ortholog vary based on the type of infection route and strain involved.