Publications by authors named "Erik Houtsma"

Article Synopsis
  • Hydroxyurea (HU) is a widely used first-line treatment for polycythemia vera (PV), but 15%-24% of patients experience resistance or intolerance to it.
  • A phase IV observational study in Europe evaluated ruxolitinib's effectiveness and safety in PV patients resistant or intolerant to HU, following 350 patients for 24 months.
  • Results showed that 68.2% of patients achieved hematocrit control, 85.1% had no need for phlebotomy during the study, and ruxolitinib was well tolerated despite some treatment-related adverse events.
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Extending on earlier work, trends in bovine tuberculosis (bTB) from 2003 to 2015 are described for the countries of the UK and the Republic of Ireland using standardised definitions and measures. Based on measures of animal and herd incidence, there remains a stable situation of extremely low prevalence in Scotland and the Low Risk Area of England, and a higher but ongoing reduction in prevalence in the Republic of Ireland. In Northern Ireland, there has been a rising bTB trend during 2010-2015, although not to levels experienced during 2002-2004.

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Ongoing objective assessment of national bovine tuberculosis (bTB) policy in Ireland is important to monitor efforts towards improved bTB control. The study objective was to investigate temporal trends in the risk of herd recurrence. The study included all herds derestricted following a bTB episode ending in 1998, 2008 or 2012.

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The European Food Safety Authority (EFSA) has published a series of opinions to assess the impact of changing from the current meat inspection procedures (CMI) to visual-only inspection (VOI) procedures. Concern has been raised that changes from CMI to VOI would adversely affect the effectiveness of surveillance for bovine tuberculosis (bTB) in EU member states, both for countries with and without official status of bTB freedom (OTF and non-OTF countries, respectively). This study was conducted to estimate the impact of a change from CMI to VOI in abattoirs on herd-level detection sensitivity in Ireland, a non-OTF country.

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Background: The dairy industry in Ireland is expanding rapidly, with a focus on the production of high quality milk. Somatic cell counts (SCC) are an important indicator both of udder health and milk quality. Milk sold by Irish farmers for manufacture must comply with EU regulations.

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