Publications by authors named "Erik Hj Danen"
Article Synopsis
- * Different types of hypoxia (acute, chronic, intermittent) affect tumor regions in varying ways, but there is no agreed-upon definition among scientists regarding their characteristics or impact on cancer cells.
- * This review aims to clarify these definitions based on hypoxia exposure duration and oxygen levels and outlines methods for future research to improve understanding of hypoxia's role in breast cancer.
Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates tumour invasiveness and micrometastasis by unknown mechanisms. To study the dynamic and reciprocal interactions between tumour cells and their microenvironment during these processes, we established a xenograft model by injecting tumour cells into the blood circulation of transparent zebrafish embryos. This reproducibly results in rapid simultaneous formation of a localized tumour and experimental micrometastasis, allowing time-resolved imaging of both processes at single-cell resolution within 1 week.
View Article and Find Full Text PDF