Hormetic Dose Response of NaAsO on Cell Proliferation of Prostate Cells in Vitro: Implications for Prostate Cancer Initiation and Therapy.

Sodium meta-arsenite (NaAsO) has been suggested to play a role both in initiation/progression of prostate cancer and as a future antiprostate cancer drug. We have studied the effects of NaAsO on cell proliferation of prostate cancer and noncancer cells, breast cancer cells, and adrenocortical carcinoma cells in vitro. Further, we have investigated the effect of NaAsO on the androgen receptor.