Effect of β - hydroxy - γ -aminophosphonate (β - HPC) on the hydrolytic activity of as determined by FT-IR spectrometry.

The use of immunomodulatory and metabolic modulating drugs has been considered a better strategy to improve the efficacy of conventional treatments against pathogens and metabolic diseases. L-carnitine is relevant in fatty acid metabolism and energy production by β-oxidation, but it also has a beneficial therapeutic immunomodulatory effect. The β-hydroxy-γ-aminophosphonate (β-HPC) was developed, synthesized and studied in different pathologies as a more soluble and stable analog than L-carnitine, which has been studied in bacterial physiology and metabolism; therefore, we set out to investigate the direct effect of β-HPC on the metabolism of , which causes actinomycetoma in Mexico and is underdiagnosed.

Fibropapillomatosis dynamics in green sea turtles Chelonia mydas over 15 years of monitoring in Akumal Bay, Quintana Roo, Mexico.

Fibropapillomatosis (FP) is a tumor disease that affects all sea turtle species but is mainly seen in green turtles Chelonia mydas. The pathology of FP has been described extensively, but its dynamics in populations over time have been less studied. We analyzed the dynamics of FP in a population of green turtles in Akumal Bay on the central coast of the Mexican Caribbean.

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer's Disease.

Worldwide, around 50 million people have dementia. Alzheimer's disease (AD) is the most common type of dementia and one of the major causes of disability and dependency among the elderly worldwide. Clinically, AD is characterized by impaired memory accompanied by other deficiencies in the cognitive domain.

National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in México.

We recently developed the National Dementia Biobank in México (BioBanco Nacional de Demencias, BND) as a unit for diagnosis, research, and tissue transfer for research purposes. BND is associated with the Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico (UNAM), Mexico. The donation of fluids, brain, and other organs of deceased donors is crucial for understanding the underlying mechanisms of neurodegenerative diseases and for the development of successful treatment.

Immunological evaluation of captive green sea turtle (Chelonia mydas) with ulcerative dermatitis.

Ulcerative dermatitis (UD) is common in captive sea turtles and manifests as skin erosions and ulcers associated with gram-negative bacteria. This study compared clinically healthy and UD-affected captive turtles by evaluating hematology, histopathology, immunoglobulin levels, and delayed-type hypersensitivity assay. Turtles with UD had significantly lower weight, reduced delayed-type hypersensitivity (DTH) responses, and higher heterophil:lymphocyte ratios.

Identification of CD3+ T lymphocytes in the green turtle Chelonia mydas.

To understand the role of the immune system with respect to disease in reptiles, there is the need to develop tools to assess the host's immune response. An important tool is the development of molecular markers to identify immune cells, and these are limited for reptiles. We developed a technique for the cryopreservation of peripheral blood mononuclear cells and showed that a commercially available anti-CD3 epsilon chain antibody detects a subpopulation of CD3 positive peripheral blood lymphocytes in the marine turtle Chelonia mydas.