Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice.

Background: Both partial-hepatectomy (PHx) and massive small bowel resection (SBR) are strong mitogenic signals to the remnant liver and intestine, respectively. This study tested the hypothesis that PHx was an additive signal for intestinal adaptation after massive SBR.

Methods: Male mice underwent either sham SBR or 50% proximal SBR.