Publications by authors named "Erik Chabriere"
Article Synopsis
- DING proteins exhibit phosphatase activity which impacts HIV-1 gene transcription by dephosphorylating key factors, specifically RNA polymerase II and NF-κB subunits.
- Experimental methods such as ELISA, northern-blot, and western-blot assays were used to show that DING proteins significantly inhibit HIV-1 infection and reduce the phosphorylation of the p65 NF-κB subunit.
- The presence of DING leads to an accumulation of hypo-phosphorylated p65 NF-κB in cells, suggesting that DING disrupts the activation and nuclear import of NF-κB, ultimately suppressing its ability to promote HIV-1 transcription.
