Publications by authors named "Erik C Schimmel"
Purpose: Female Hodgkin lymphoma (HL) survivors treated with chest radiotherapy (RT) at a young age have a strongly increased risk of breast cancer (BC). Studies in childhood cancer survivors have shown that doxorubicin exposure may also increase BC risk. Although doxorubicin is the cornerstone of HL chemotherapy, the association between doxorubicin and BC risk has not been examined in HL survivors treated at adult ages.
View Article and Find Full Text PDFBackground: We studied whether hormonal therapy, (neo)adjuvant to radiotherapy for localized prostate cancer, is related to an increase in depression and whether this is caused by the hormonal therapy itself or by the relatively poor prognosis of patients who get (neo)adjuvant hormonal therapy.
Methods: Between 2002 and 2005, 288 patients, irradiated for prostate cancer (T1-3N0M0), were studied prospectively in two clinics. In one clinic almost all patients received (neo)adjuvant androgen deprivation (Bicalutamide+Gosereline).
Low-dose palliative radiotherapy for cutaneous B- and T-cell lymphomas.
Int J Radiat Oncol Biol Phys
May 2009
Article Synopsis
- The study aimed to evaluate the effectiveness of low-dose palliative radiotherapy for two types of skin lymphomas: cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis fungoides).
- A group of 18 patients with CBCLs showed a 72% complete response rate to low-dose radiotherapy, while initial treatment for mycosis fungoides was less effective (70% failure rate) until the dose was increased to 8 Gy, resulting in a 92% complete response.
- The findings suggest that low-dose radiotherapy is a safe and effective palliative treatment for these skin lymphomas, and higher doses can be employed if needed after initial treatment failures
Purpose: To examine, in prostate cancer patients, the effect of (1) being offered a choice between radiation doses in three-dimensional conformal radiotherapy, and of (2) accepting or declining the possibility to choose.
Methods And Materials: A total of 150 patients with localized prostate cancer (T1-3N0M0) were offered a choice with a decision aid between two radiation doses (70 and 74 Gy). A control group of 144 patients received a fixed radiation dose without being offered a choice.
Do prostate cancer patients want to choose their own radiation treatment?
Int J Radiat Oncol Biol Phys
November 2006
Purpose: The aims of this study were to investigate whether prostate cancer patients want to be involved in the choice of the radiation dose, and which patients want to be involved.
Methods And Materials: This prospective study involved 150 patients with localized prostate cancer treated with three-dimensional conformal radiotherapy. A decision aid was used to explain the effects of two alternative radiation doses (70 and 74 Gy) in terms of cure and side effects.
Purpose: To evaluate the long-term risk of cardiovascular disease (CVD) in survivors of testicular cancer (TC).
Patients And Methods: We compared CVD incidence in 2,512 5-year survivors of TC, who were treated between 1965 and 1995, with general population rates. Treatment effects on CVD risk were quantified in multivariate Cox regression analysis.
Purpose: A higher radiation dose is believed to result in a larger probability of tumor control and a higher risk of side effects. To make an evidence-based choice of dose, the relation between dose and outcome needs to be known. This study focuses on the dose-response relation for prostate cancer.
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