Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review.

Background: Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of refractory epilepsy in these patients.

Objective: To evaluate the efficacy of everolimus in controlling refractory epilepsy in children with TS.