[Minoxidil-induced ophthalmic hypertension (case report)].

This article presents a case of a 31-year-old male patient who presented to the outpatient department of the Krasnov Research Institute of Eye Diseases with complaints of diplopia and increased intraocular pressure (IOP) up to 30 mm Hg. The patient had been using minoxidil topically for androgenic alopecia for 8 years. On examination, mild swelling of the bulbar conjunctiva in the upper fornix was revealed; optical coherence tomography showed thinning of the ganglion cell layer, most likely due to moderate myopia.

[Role of point-by-point light sensitivity in the assessment of glaucoma progression].

Purpose: This study analyzes changes in light sensitivity in each test point of the visual field in patients with different stages of glaucoma.

Material And Methods: The data of a prospective analytical case-control study were analyzed. All patients underwent assessment of retinal light sensitivity and its variability in 54 points corresponding to the 24-2 program.

[Static automated perimetry in the diagnosis of glaucoma. Assessment of disease progression].

There are several ways to assess glaucoma progression using standard automated perimetry. Most often, ophthalmologists evaluate the stability of visual functions manually when comparing several study protocols. The advantages of clinical assessment are ease of implementation and the ability to interpret data from any device.

[The effect of keratoconus-associated refractive errors on the results of tomographic methods of studying the posterior structures of the eye].

Purpose: The study assesses the potential influence of refractive errors in keratoconus (KC) on the results of tomographic methods of studying the structures of the posterior eye segment.

Material And Methods: The study included 30 patients with bilateral stabilized KC of stages I-IV in classification by M. Amsler.

[Modern achievements in the diagnosis and treatment of glaucoma].

Glaucoma is one of the most difficult and significant ocular conditions. The chronic asymptomatic course of glaucoma progression leads to irreversible deterioration of visual functions. Many aspects of its pathogenesis, the features of its clinical presentation, diagnosis and treatment have been identified in recent years.

[Contribution of Academician M.M. Krasnov to ophthalmological science and practice].

The scientific legacy of Professor Mikhail Mikhailovich Krasnov, Academician of the Russian Academy of Medical Sciences, is large and multifaceted. His name is associated with the whole epoch of establishment and development of new methods of diagnostics and treatment of eye diseases. The representative of the dynasty of ophthalmologists M.

[Ocular hypertension after intravitreal injections].

Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) for the treatment of age-related macular degeneration with choroidal neovascularization have become much more popular nowadays. Anti-VEGF therapy is generally well-tolerated; however, one of its possible side effects is ocular hypertension - elevation of intraocular pressure (IOP) above the accepted norm, but without structural and functional changes in the retina and optic nerve common for glaucoma. The average duration of IOP elevation is 30 to 60 minutes, but it can increase when the patient has primary open-angle glaucoma (POAG).

[Gerontological aspects of eye diseases].

The global rate of aging is rapidly rising due to the increase in life expectancy, and the number of age-related diseases - including eye diseases - is increasing. The most common eye conditions affecting people over 50 years old are age-related macular degeneration, cataract, glaucoma and diabetic retinopathy. Timely and effective treatment of age-related eye diseases requires a deeper understanding of the cellular mechanisms of aging.

[Comparative evaluation of hypotensive effectiveness of topical monotherapy and selective laser trabeculectomy].

Purpose: Comparison of the hypotensive effects of selective laser trabeculoplasty (SLT) and drug therapy in patients with newly diagnosed primary open-angle glaucoma (POAG) and ocular hypertension.

Material And Methods: Thirty patients (30 eyes) with newly diagnosed ophthalmic hypertension or POAG were observed. Patients of the 1st group (15 eyes) underwent standard SLT as a starting treatment, patients of the 2nd group (15 eyes) were prescribed monotherapy with a prostaglandin analog.

[Prostaglandins in ophthalmology].

Prostaglandins are widely used in medicine as active physiological agents that form a new class of drugs for treatment of cardiovascular diseases, some forms of bronchial asthma, as well as in gynecology and ophthalmology. Development of aseptic inflammation is an example of intracellular process, in which the produced prostaglandins are able to and do cause vasodilatation, increased vascular permeability, pain and fever. These effects of prostaglandins and leukotrienes characterize the classic picture of inflammation, including the aseptic one.

[Professor Eduard Sergeevich Avetisov (to the 100th anniversary of his birth)].

Domestic ophthalmology has many bright names in its history, which have become the pride and heritage of the country. One of them is the name of the outstanding Soviet ophthalmologist Professor Eduard Sergeyevich Avetisov. This year marks the 100th anniversary of the scientist's birth, but his contribution to Soviet medical science has become more and more visible over the years, has not lost its academic relevance, social importance and relevance, remaining a solid foundation for the development of modern trends in the field of vision protection for children.

[Challenges of long-term glaucoma therapy].

Primary open-angle glaucoma (POAG) is among the most common causes of irreversible loss of visual functions, its early diagnosis and treatment present great difficulties. POAG development involves many mechanical, hemodynamic and metabolic factors. The main approach to its treatment is reduction and normalization of the intraocular pressure (IOP), starting with local antihypertensive therapy.

[The role of vitreous body in pathogenesis of glaucoma].

This literature review provides modern information on the unique structure of the vitreous body, its functions, and its role in the pathogenesis of glaucoma, describes the features of the vitreous morphology and metabolism, notes its biomechanical and trophic functions, outlines its role in healthy hydrodynamics and hemodynamics of the eye, as well as in aqueous humor outflow. The review presents clinical observations on the association of pathological changes in the vitreous body with glaucoma development and examines the role of involutional changes in the vitreous in the pathogenesis of glaucoma. The article also discusses possible pathogenetic mechanisms of glaucoma development in terms of pathological changes in the vitreous.

[Static automated perimetry in the diagnosis of glaucoma. Part 2: Research protocol, glaucoma classifications, perimetric defects through the prism of structural-functional correlation].

Examination of the central visual field is currently required for glaucoma diagnosis. Modern computer perimeters make it possible to qualitatively and quantitatively evaluate defects of light sensitivity. Perimetric indices are calculated showing the severity of the defects.

[Static automated perimetry in the diagnosis of glaucoma. Part 1: Basic principles].

Static automated perimetry is an indispensable tool in the diagnosis of glaucoma. It is used to study the differential light sensitivity of the retina in different points of the visual field. The most important is the central zone of the visual field, many perimetric programs and strategies have been developed for its examination.

[Current trends in studying pathogenesis of glaucoma].

Glaucoma is a group of neurodegenerative disorders comprising one of the main causes of irreversible blindness. Glaucoma-related blindness is a globally relevant problem. By now, many aspects of glaucoma pathogenesis have been studied: impact of increased intraocular pressure (IOP) on the development of optic neuropathy, ischemia and reperfusion of the retina, most of the direct mechanisms of neuronal death (excitotoxicity, oxidative stress, etc).

[Frequency and nature of intraoperative and early postoperative complications after glaucoma surgeries].

Purpose: To study the frequency and nature of intraoperative and early postoperative complications after glaucoma surgeries depending on several factors.

Material And Methods: The study retrospectively analyzed 87 outpatient records and case histories of patients with primary open-angle glaucoma (POAG). All subjects had undergone standard trabeculectomy.

[Thermography of ocular surface tissues in the assessment of aseptic postoperative inflammation].

Purpose: To determine the thermographic parameters of ocular surface tissues in various types of anti-glaucoma operations.

Material And Methods: The study included 70 patients with glaucoma (140 eyes) and 28 patients (56 eyes) with cataract and planned phacoemulsification. All patients underwent dynamic infrared thermography of the eye surface to evaluate the aseptic inflammatory response before and after surgery.

[The influence of long-term retinal protective therapy on glaucoma progression according to structural and functional tests].

Purpose: To evaluate the influence of prolonged neuroprotective therapy on disease progression in patients with primary open-angle glaucoma (POAG) with compensated intraocular pressure (IOP).

Material And Methods: The study included 147 patients with stages I-II POAG (249 eyes) who were randomized into the main (69 patients, 119 eyes) and control groups (78 patients, 130 eyes). Patients of the main group underwent retinalamin treatment course every 6 months.

[Peptide bioregulators: delivery and efficacy].

Purpose: To compare the neuroprotective properties of retinalamin administered in different ways among open-angle glaucoma patients with compensated intraocular pressure.

Material And Methods: The study included 498 patients (eyes) with initial, moderate and advanced stages of glaucoma. Patients were divided into 3 groups: group I (=110) received 5 mg intramuscular and 5 mg retrobulbar injections of retinalamin; group II (=171) received 5 mg retrobulbar injection of retinalamin; group III received 5 mg intramuscular injection of retinalamin.

[Continuous anti-glaucoma drug therapy as a risk factor of dry eye].

A preservative is a mandatory component of the eye drops designed to prevent microbial contamination in an opened bottle. Most of the preservative agents are either detergents, or oxidants; the most widely used and well-studied preservative - benzalkonium chloride - is a detergent. Due to regular usage of glaucoma eye drops, cytotoxic impact of the preservatives on anterior eye surface is considered the principal cause of its pathology, which leads to a decrease in quality of life.

[Modern view on ocular hypertension].

Increased intraocular pressure is the main, and the only modifiable risk factor in the development of glaucoma. This review analyzes studies on differential diagnostics of ocular hypertension and risk factors of its conversion to glaucoma, and gives recommendations based on literature data for the most correct algorithm for management of patients with ocular hypertension.

[Frequency and type of macular edema after cataract surgery in patients with glaucoma].

Cataract is one of the common causes of reversible vision loss in people older than 50 years. Currently, the only way to treat it effectively is phacoemulsification with simultaneous implantation of an intraocular lens - a method that minimizes the amount of surgical trauma and the number of intra- and postoperative complications. Nevertheless, the problem of prevention and timely diagnosis of pathological changes in the retina, which may develop after extraction of cataracts, and in particular - macular edema, remains relevant.

[Dynamics of changes in morphometric parameters of the macular zone in glaucoma patients after phacoemulsification].

Purpose: To analyze the dynamics of morphometric changes in the macular zone using optical coherence tomography (OCT) data in patients with primary open-angle glaucoma (POAG) after phacoemulsification (PE).

Material And Methods: The study enrolled 93 patients (95 eyes) requiring PE; they were divided into 2 groups. The first (control) group consisted of 30 patients (32 eyes) without concomitant eye pathology.

[Diode and argon trabeculoplasty in primary open-angle glaucoma treatment].

Laser trabeculoplasty is one of the methods used to decrease intraocular pressure (IOP) as part of comprehensive glaucoma treatment. Argon laser trabeculoplasty (ALT) and diode laser trabeculoplasty (DLT) are two of the most widely used laser trabeculoplasty techniques. The mechanism of its hypotensive action is based on the effect that laser emission photocoagulate has on trabecular meshwork and subsequent outflow facilitation, but the difference in wavelength and emission energy determine the difference in direct laser action and the features of postoperative clinical appearance.