Publications by authors named "Erica Sauro"
Article Synopsis
- Maternal and fetal pregnancy outcomes vary depending on fetal sex, possibly due to differing epigenetic regulation of RNA in the placenta.
- A study using next-generation sequencing found distinct miRNA expression profiles in both first and third trimesters of uncomplicated pregnancies, revealing sexually dimorphic miRNAs, especially upregulated in females.
- The research identified a total of 986 expressed miRNAs and provided a comprehensive atlas of these miRNAs, which may help identify biomarkers for placental function and explore sex differences in placental biology.
Article Synopsis
- Researchers explored miRNA changes in healthy human placentae during pregnancy to help use them as biomarkers later on.
- They analyzed the miRNome in both the first and third trimesters, identifying 801 expressed miRNAs, with 182 remaining stable and 180 showing significant changes across gestation.
- The study highlights specific miRNA clusters on chromosomes 14, 19, and 13 that vary in expression, providing a detailed resource for future investigation into pregnancy-related epigenetic differences.
