Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes.

Heart failure is a multifaceted syndrome contributing significantly to mortality and hospitalization rates among the global population. One of the prevalent causes of heart failure is ischemic heart disease (IHD), often caused by a blockage in a coronary artery, ultimately leading to the loss of myocardial tissue and contractile force. The impact of this ischemic ambiance on the cardiomyocyte genome and transcriptome has not been thoroughly studied.