Publications by authors named "Erica MacKenzie"
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season.
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- A multicenter study examined the effects of adjunctive glucocorticoid therapy (AGT) on all-cause ICU admission and death rates among solid organ transplant recipients (SOTRs) with Pneumocystis jirovecii pneumonia (PJP) across several countries.
- The study included 172 SOTRs with an average age of 60, and found ICU admission rates at 43.4% and death rates at 20.8%.
- Results showed that AGT did not significantly lower the risk of ICU admission, death, or improve respiratory function, indicating a need to reconsider its routine use in PJP treatment for SOTRs and call for further research.
Current and Emerging Therapies for COVID-19 in Lung Transplantation.
Curr Pulmonol Rep
February 2023
Article Synopsis
- - The COVID-19 pandemic has evolved over the past three years, leading to significant new findings in epidemiology, transmission, diagnosis, and treatment, particularly for lung transplant recipients.
- - Research has highlighted several key therapeutics for COVID-19, including antivirals like remdesivir and nirmatrelvir/ritonavir, monoclonal antibodies, and immunomodulators such as corticosteroids.
- - Remdesivir is crucial for treating mild to moderate cases, while the use of nirmatrelvir in lung transplant patients is limited due to drug interactions; monoclonal antibodies struggle with varying viral strains.
colonization and the frequency of subsequent treatment for infection in critically ill patients.
Infect Control Hosp Epidemiol
November 2023
Objective: To determine risk factors for colonization and infection (CDI) among patients admitted to the intensive care unit (ICU).
Design: Retrospective observational cohort study.
Setting: Tertiary-care facility.
Lung transplantation has lower survival rates compared to other than other solid organ transplants (SOT) due to higher rates of infection and rejection-related complications, and bacterial infections (BI) are the most frequent infectious complications. Excess morbidity and mortality are not only a direct consequence of these BI, but so are subsequent loss of allograft tolerance, rejection, and chronic lung allograft dysfunction due to bronchiolitis obliterans syndrome (BOS). A wide variety of pathogens can cause infections in lung transplant recipients (LTRs), including a number of nosocomial pathogens and other multidrug-resistant (MDR) pathogens.
View Article and Find Full Text PDFObjective: To determine clinical characteristics associated with false-negative severe acute respiratory coronavirus virus 2 (SARS-CoV-2) test results to help inform coronavirus disease 2019 (COVID-19) testing practices in the inpatient setting.
Design: A retrospective observational cohort study.
Setting: Tertiary-care facility.
Objective: Obesity has been identified as a risk factor for severe coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 virus. This study sought to determine whether obesity is a risk factor for mortality among patients with COVID-19.
Methods: The study was a retrospective cohort that included patients with COVID-19 between March 1 and April 18, 2020.
Background: Vasoactive medications are commonly used in the treatment of critically ill patients, but their impact on the development of ICU-acquired weakness is not well described. The objective of this study is to evaluate the relationship between vasoactive medication use and the outcome of ICU-acquired weakness.
Methods: This is a secondary analysis of mechanically ventilated patients (N = 172) enrolled in a randomized clinical trial of early occupational and physical therapy vs conventional therapy, which evaluated the end point of ICU-acquired weakness on hospital discharge.
Objectives: Many survivors of acute respiratory distress syndrome have poor long-term outcomes possibly due to supportive care practices during "invasive" mechanical ventilation. Helmet noninvasive ventilation in acute respiratory distress syndrome may reduce intubation rates; however, it is unknown if avoiding intubation with helmet noninvasive ventilation alters the consequences of surviving acute respiratory distress syndrome.
Design: Long-term follow-up data from a previously published randomized controlled trial.