Background: Above-the-knee amputations (AKA) are common surgeries that frequently use neuraxial or peripheral nerve blocking techniques for both intraoperative and postoperative analgesia. It is not uncommon that patients present with contraindications to neuraxial anesthesia.
Case Presentation: We identified a relatively novel use of erector spinae plane block (ESP) for above-the-knee amputation that allows for adequate pain control postoperatively when there are contraindications for neuraxial.