A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects.

Purpose: This study compares the pharmacokinetic (PK) profile, adhesion, and safety of lidocaine topical system 1.8%, a novel lidocaine topical system approved to treat postherpetic neuralgia, under conditions of heat and exercise vs normal conditions.

Materials And Methods: This open-label, 3-period, 3-treatment crossover study randomized 12 healthy adults to receive three lidocaine topical systems 1.

The CDC Opioid Guideline: Proponent Interpretation Has Led to Misinformation.

Pain management epitomizes the value of a multidisciplinary approach to caring for patients, yet regrettably, the term pain management has too often become synonymous with prescribing opioids only. Optimal chronic pain management requires a skillset most conducive to a multidisciplinary team approach and should be performed in a scientifically and clinically sound manner. It is with these facts in mind that we offer our view of the Centers for Disease Control and Prevention (CDC) Guideline for Prescribing Opioids for Chronic Pain.

Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes.

The use of pharmacogenomics has become more prevalent over the past several years in treating many disease states. Several cytochrome P450 enzymes play a role in the metabolism of many pain medications including opioids and antidepressants. Noncytochrome P450 enzymes such as methylenetetrahydrofolate reductase (MTHFR) and catechol--methyl transferase (COMT) also play a role in the explanation of opioid dosage requirements as well as in response to certain antidepressants.