Publications by authors named "Erica G B Chapola"
Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira. Bacteria disseminate via the bloodstream and colonize the renal tubules of reservoir hosts. Leptospiral surface-exposed proteins are important targets, because due to their location they can elicit immune response and mediate adhesion and invasion processes.
View Article and Find Full Text PDFArticle Synopsis
- The study identifies and characterizes two novel proteins from Leptospira interrogans, named Lsa19 and Lsa14, which are involved in binding to the extracellular matrix.
- Both proteins are surface-exposed and bind to laminin in a dose-dependent manner, indicating their potential role in infection processes.
- Lsa19 shows reactivity with antibodies from leptospirosis patients, suggesting its expression during infection, while the presence of a sigma factor hints at its additional role in host-pathogen interactions.
The biodiversity of potential leptospiral reservoir hosts is lower in urban than in rural environments. Previous data indicate the potential for bats to act as carriers of Leptospira in regions such as the Amazon of South America and in Australia. Yet, little is known about the contribution of bats to leptospirosis in urban environments in South America.
View Article and Find Full Text PDFSera from humans and dogs were tested by microscopic agglutination test. Icterohaemorrhagiae was the predominant serogroup in both groups, associated with the infestation of Rattus norvegicus.
View Article and Find Full Text PDF