A comparative study between Cu(INA)-MOF and [Cu(INA)(HO)] complex for a click reaction and the Biginelli reaction under solvent-free conditions.

The catalytic activity of metal-organic framework Cu(INA) (INA = isonicotinate ion) and the complex [Cu(INA)(HO)] were studied in the Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC) and Biginelli reaction under solvent-free reaction conditions. The robust, efficient and eco-friendly new method allowed the preparation of a variety of 1,2,3-triazole compounds in good to excellent yields and high selectivity for the 1,4-disubstituted triazole. Moreover, for the Biginelli reaction between aldehydes, ethyl acetoacetate and urea, the corresponding dihydropyrimidinones (DHPMs) were also obtained in satisfactory yields under mild reaction conditions for both catalysts.