Publications by authors named "Erica Blenda da Silva"
Neurotox Res
February 2022
Article Synopsis
- Manganese is an essential metal for bodily functions, but excessive amounts can lead to neurotoxicity and a condition similar to Parkinson's known as manganism.
- This study explored the protective effects of probucol, an anti-inflammatory and antioxidant lipid-lowering agent, against manganese-induced toxicity in human neuroblastoma (SH-SY5Y) and glioblastoma (C6) cell lines.
- Results showed that while higher concentrations of manganese reduced cell viability, probucol effectively countered these effects by preventing mitochondrial dysfunction and lowering harmful reactive oxygen species (ROS) levels.
