Publications by authors named "Erica A Wetzler"
Background: Hybrid immunity (infection plus vaccination) may increase maternally derived SARS-CoV-2 antibody responses and durability versus infection alone.
Methods: Prospective cohort of pregnant participants with prior SARS-CoV-2 infection (anti-nucleocapsid IgG, RT-PCR, or antigen positive) and their infants had blood collected in pregnancy, at delivery/birth, and postpartum tested for anti-spike (anti-S) IgG and neutralizing antibodies (neutAb).
Results: Among 107 participants at enrollment, 40% were unvaccinated and 60% were vaccinated (received ≥1 dose); 102 had previous SARS-CoV-2 infection in pregnancy (median, 19 weeks' gestation); 5 were diagnosed just prior to pregnancy (median, 8 weeks).
Article Synopsis
- Antenatal care can help assess the prevalence of antibodies against COVID-19 and their duration in pregnant individuals, which could be important for protecting both mothers and newborns during and after pregnancy.
- The study involved screening pregnant people in Seattle for COVID-19 antibodies and included both a cross-sectional study to measure prevalence and a prospective cohort study to analyze antibody responses over time.
- Results showed that 5% of the individuals screened had COVID-19 antibodies, with some being asymptomatic; in the cohort study, 80% of participants were found to have antibodies during pregnancy, although nearly half lost these antibodies by the time of delivery.*
Malaria was the leading cause of post-neonatal deaths in Mozambique in 2017. The use of insecticide treated nets (ITNs) is recognized as one of the most effective ways to reduce malaria mortality in children. No previous analyses have estimated changes in mortality attributable to the scale-up of ITNs, accounting for provincial differences in mortality rates and coverage of health interventions.
View Article and Find Full Text PDFBackground: Roraima state is the northernmost state in Brazil and the primary border-crossing point between Brazil and Venezuela. The uncontrolled surge of malaria in Venezuela, coupled with mass migration of Venezuelans to neighbouring countries and the upward trend in informal mining in the state, pose a serious threat to the broader region, especially to migrant, indigenous and mining populations, jeopardizing malaria elimination efforts. This study describes changes in the epidemiological profile of malaria in Roraima state related to time, place and populations at risk from 2016 to 2020.
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