Publications by authors named "Erica A Rangel"
Bioorg Med Chem
December 2006
Article Synopsis
- The study focused on creating and testing new compounds called N-substituted-phenyl-1,2,3-triazole-4-carbaldehydes (3a-l) for their effectiveness against Mycobacterium tuberculosis.
- The compounds were synthesized through reactions of aromatic amines and showed promising anti-tubercular activity, especially compounds 3a and 3k, which had similar effectiveness to existing tuberculosis drugs.
- A structure-activity relationship (SAR) analysis revealed that factors like the presence of hydrogen bond acceptors and the arrangement of aromatic rings significantly impacted the compounds' anti-tubercular properties, highlighting 3a and 3k as potential candidates for future research.
