Publications by authors named "Eric de Smet"

To eliminate onchocerciasis-associated morbidity, it is important to identify areas where there is still high ongoing transmission. Between 2015 and 2021, door-to-door surveys were conducted in onchocerciasis-endemic villages in Cameroon, the Democratic Republic of Congo (DRC), Nigeria, South Sudan, and Tanzania to determine epilepsy prevalence and incidence, type of epilepsy and ivermectin therapeutic coverage. Moreover, children aged between six and 10 years were tested for anti- antibodies using the Ov16 IgG4 rapid diagnostic test (RDT).

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Article Synopsis
  • Nodding Syndrome (NS) is a severe form of childhood epilepsy primarily found in East Africa, characterized by repetitive head nodding, with unknown causes; this study aimed to identify cases in the Central African Republic (CAR).
  • A door-to-door survey was conducted in a village near Bangui, identifying 5 cases of NS among girls aged 8 to 16, with various clinical characteristics and neurological abnormalities confirmed by a neurologist.
  • This study marks the first reported cases of Nodding Syndrome in CAR, highlighting the need for further research in the area to explore potential connections with Onchocerca volvulus and assess the overall prevalence of the condition.
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Article Synopsis
  • Recent reports indicated a high number of epilepsy cases, particularly nodding seizures, in Landja Mboko, Central African Republic, leading to concerns about onchocerciasis transmission in the area.
  • An antibody prevalence study among children aged 6-9 revealed an 8.9% seroprevalence for Ov16 and 1.9% for lymphatic filariasis, with the highest positivity observed in the Kodjo village.
  • The findings suggest ongoing transmission of onchocerciasis, prompting recommendations to map the extent of the outbreak and consider implementing ivermectin mass drug distribution in the affected communities.
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Natalizumab (Tysabri(®)) is highly efficacious in controlling disease activity in relapsing multiple sclerosis (MS) patients. As it is one of the more recent therapies for MS, there remains a need for long-term safety and efficacy data of natalizumab in a clinical practice setting. The Tysabri observational program (TOP) is an open-label, multicenter, multinational, prospective observational study, aiming to recruit up to 6,000 patients with relapsing-remitting MS from Europe, Canada and Australia.

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Apraxic agraphia is a peripheral writing disorder caused by neurological damage. It induces a lack or loss of access to the motor engrams that plan and programme the graphomotor movements necessary to produce written output. The neural network subserving handwriting includes the superior parietal region, the dorsolateral and medial premotor cortex and the thalamus of the dominant hemisphere.

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Some cases of nephrotic syndrome in focal and segmental glomerulosclerosis (FSGS) are associated with a circulating factor, the FSGS permeability factor (FSPF). Galactose has a high affinity for FSPF, and experimental data suggest that it could reduce its activity. We describe the case of a 48-year-old male with a nephrotic syndrome found to be resistant to corticosteroids, immunosuppression and plasmaphaeresis.

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