The Production of Antibiotic Cement Beads.

The use of antibiotic beads in open fracture cases can lead to decreased rates of infection and surgeon production is associated with significant time and cost savings. This video demonstrates production of antibiotic impregnated polymethylmethacrylate beads used in the setting of a grade IIIB open tibial shaft fracture.

Tibial Intramedullary Nail From a Suprapatellar Approach in a Semi-Extended Position.

An intramedullary nail is a common and reliable treatment option for diaphyseal tibial fractures. One such approach for this technique is suprapatellar. This video shows the surgical technique of a tibial nail through a suprapatellar approach in a semi-extended position in a 22-year-old man with a distal third tibial shaft fracture.

Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential.

Background: Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previous studies have linked chromosomal instability (CIN), which generates aneuploidy following chromosomal missegregation during mitosis, to PC progression.

Posterior Approach for a Cemented Hemiarthroplasty.

Purpose: Femoral neck fractures are common injuries with over 1 million occurring yearly. This video demonstrates a case of a displaced femoral neck fracture treated with a cemented hemiarthroplasty through a posterior approach.

Methods: Multiple approaches to the hip for arthroplasty have been described, each with advantages and disadvantages.

Direct Anterior Approach for Hip Hemiarthroplasty.

Purpose: The purpose of this video is to demonstrate a surgical technique for a hemiarthroplasty of the hip joint through a direct anterior approach. We have found this technique to be a viable option for the treatment of displaced femoral neck fractures.

Methods: Multiple approaches to the hip are described for arthroplasty.

Radial Head Replacement Through a Kocher Approach.

Purpose: Radial head fractures are some of the most common elbow fractures. Fractures with 3 or more fracture fragments have been shown to have worse outcomes when treated with open reduction and internal fixation (ORIF). Radial head replacement offers an alternative treatment for those more comminuted radial head fractures.

Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis.

Tumor heterogeneity is prevalent in both treatment-naïve and end-stage metastatic castration-resistant prostate cancer (PCa), and may contribute to the broad range of clinical presentation, treatment response, and disease progression. To characterize molecular heterogeneity associated with metastatic PCa, multiplatform single cell profiling was performed using high definition single cell analysis (HD-SCA). HD-SCA enabled morphoproteomic and morphogenomic profiling of single cells from touch preparations of tissue cores (prostate and bone marrow biopsies) as well as liquid samples (peripheral blood and bone marrow aspirate).

Anatomic and Molecular Imaging in Prostate Cancer.

Prostate cancer is characterized by a complex set of heterogeneous disease states. This review aims to describe how imaging has been studied within each specific state. As physicians transition into an era of precision medicine, multiparametric magnetic resonance imaging (mpMRI) is proving to be a powerful tool leading the way for a paradigm shift in the diagnosis and management of localized prostate cancer.

Impact of treatment on progression to castration-resistance, metastases, and death in men with localized high-grade prostate cancer.

Men with high-grade prostate cancer (HGPC) are at greatest risk of disease progression. Clinical risk factors associated with castration-resistant prostate cancer (CRPC), metastases, and prostate cancer-specific mortality (PCSM) were identified in a contemporary HGPC cohort. Clinical data was collected from men diagnosed with Gleason sum (GS) ≥8 at the Greater Los Angeles Veterans Affairs (GLA-VA) Healthcare System between 2000 and 2013.

DETERMINATION OF OXALATE ION DOPANT LEVEL IN POLYPYRROLE USING FT-IR.

A pellet method using standard addition and FT-IR was used to estimate oxalate ion doping levels in electrosynthesized polypyrrole. The method is useful for materials where removal of analyte from an insoluble material is problematic. Here, electrosynthesized oxalate doped polypyrrole is dispersed in potassium bromide.

Outcomes of shipped live donor kidney transplants compared with traditional living donor kidney transplants.

The disparity between kidney transplant candidates and donors necessitates innovations to increase organ availability. Transporting kidneys allows for living donors and recipients to undergo surgery with a familiar transplant team, city, friends, and family. The effect of shipping kidneys and prolonged cold ischemia time (CIT) with living donor transplantation outcomes is not clearly known.

Using established predictors of post-traumatic stress to explain variations in recovery outcomes among orthopedic patients.

The present studies examine whether information contained in medical records can be used to predict outcomes following two orthopedic procedures: repair of hip fracture and total knee replacement. Study 1 reports the acute, in-hospital recovery data from the medical records of 119 hip fracture patients. Study 2 is a prospective, longitudinal investigation of 3-month postoperative recovery of 110 total knee replacement patients.

Extended Neviaser portal approach to antegrade humeral nailing.

Certain arthropathies can distort the normal acromiohumeral relationship and make traditional anterolateral access to the proximal humerus for nailing difficult or impossible. This article presents a case of bilateral antegrade humeral nailing in which the Neviaser portal approach was used for humeral shaft fractures in a patient with distorted shoulder anatomy secondary to severe cuff tear arthropathy and rheumatoid arthritis. Based on a literature review, extending the traditional superomedial (Neviaser) portal to the shoulder to perform humeral nailing has never been described clinically.

"Living independently is good": residence patterns in rural north China reconsidered.

Filialpiety provides an important ideological basis for family-based support in China. Evidence indicates that in recent years the support of the aged within the Chinese extended family has decreased. This article examines filial piety, residence, and support arrangements in three rural Chinese villages.