Dietary ω-3 fatty acids and the incidence of atrial fibrillation in the Million Veteran Program.

Background: Although recent large randomized clinical trials have reported an increased risk of atrial fibrillation (AF) with marine ω-3 fatty acid supplements, it is unclear whether dietary marine ω-3 fatty acids assessed through food frequency questionnaires are associated with AF risk.

Objectives: We sought to test the hypothesis that dietary eicosapentaenoic acid/docosahexaenoic acid/docosapentaecnoic acid (EPA/DHA/DPA) is associated with a higher risk of AF in a large prospective cohort of US Veterans.

Methods: We analyzed data from Million Veteran Program participants who completed self-reported food frequency questionnaires.

Predictive value of ASCVD risk score for mortality and major adverse cardiovascular events in the year following a COVID-19 infection among US Veterans.

Background: Morbidity and mortality following COVID-19 infection may be influenced by baseline atherosclerotic cardiovascular disease (ASCVD) risk, yet limited data are available to identify those at highest risk. We examined the association between baseline ASCVD risk with mortality and major adverse cardiovascular events (MACE) in the year following COVID-19 infection.

Methods: We evaluated a nationwide retrospective cohort of US Veterans free of ASCVD who were tested for COVID-19.

Performance of EHR classifiers for patient eligibility in a clinical trial of precision screening.

Background: Validated computable eligibility criteria use real-world data and facilitate the conduct of clinical trials. The Genomic Medicine at VA (GenoVA) Study is a pragmatic trial of polygenic risk score testing enrolling patients without known diagnoses of 6 common diseases: atrial fibrillation, coronary artery disease, type 2 diabetes, breast cancer, colorectal cancer, and prostate cancer. We describe the validation of computable disease classifiers as eligibility criteria and their performance in the first 16 months of trial enrollment.

Synthesis and structure of palladium(II) complexes supported by -NHC pincer ligands for the electrochemical activation of CO.

A series of -NHC pincer complexes of palladium(II) have been prepared and characterized. These pyridyl-spaced dicarbene complexes ( ) were synthesized with substituents of varying steric bulk at the wingtip positions, which include R = methyl, ethyl, isopropyl, cyclohexyl, mesityl and 2,6-diisopropylphenyl. The synthesis of this library of complexes was accomplished either by direct metallation of the prerequisite pyridyl-spaced -imidazolium proligands with Pd(OAc) or via treatment with AgO to afford the corresponding silver carbenes, which were then transmetallated onto palladium.