Efficacy and safety of deracoxib for control of postoperative pain and inflammation associated with soft tissue surgery in dogs.

Objective: To investigate the effectiveness and safety of deracoxib (Deramaxx®) administered at a dose of 1-2 mg/kg/day for 3 days for control of postoperative pain and inflammation associated with soft tissue surgery in dogs.

Study Design: Prospective, randomized, blinded, placebo-controlled, multi-center clinical study.

Animals: Dogs (n = 34).

Efficacy and safety of deracoxib for the control of postoperative pain and inflammation associated with dental surgery in dogs.

The efficacy and safety of deracoxib administered at 1-2 mg/kg/day for 3 days was assessed for the control of postoperative pain and inflammation associated with dental surgery in dogs. Client-owned dogs scheduled for dental extractions were premedicated with butorphanol and randomly assigned to receive either deracoxib (n = 31) or placebo (n = 31) preoperatively and again once daily for 2 additional days. Dogs were evaluated prior to and after surgery using a modified Glasgow Composite Pain Scale (mGCPS).

Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity in cats.

Objective: To assess the correlation between data generated by an accelerometer-based activity monitor and the distance moved in cats.

Study Design: Prospective experimental study.

Animals: Three, four-year-old, male, purpose-bred research cats, weighing between 5.

Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis.

Background: There are no validated systems for measuring pain from osteoarthritis in cats.

Hypothesis: Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.

Animals: Thirteen cats older than 10 years old, with owner-assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.

Biomechanical comparison of dual interlocking single loop and double loop tension band techniques to the classic AO tension band technique for repair of olecranon osteotomies in dogs.

Objective: To compare olecranon fragment stability between the classic tension band wire (TBW) technique with the wire placed either in contact with (Arbeitsgemeinschaft für Osteosynthesefragen [AO]), or not in contact with, a Kirschner (K)-wire (AOW) to 2 novel wire patterns: a dual interlocking single loop (DISL) and a double loop (DL).

Study Design: Ex vivo mechanical evaluation on cadaveric bones.

Sample Population: Canine ulnae (n=40) with olecranon osteotomies repaired with 2 K-wires and 1 of 4 TBW constructs.

Pharmacogenetic analysis of sex differences in opioid antinociception in rats.

Sex differences in opioid antinociception have been reported in rodents and monkeys, with opioids being more potent in males than females. In the present study, the influence of rat strain on sex differences in opioid antinociception was examined in a warm water tail-withdrawal procedure. Antinociceptive tests were conducted with the high-efficacy micro-opioid morphine, and the less efficacious opioids buprenorphine, butorphanol and nalbuphine.

Capsaicin-induced hyperalgesia and mu-opioid-induced antihyperalgesia in male and female Fischer 344 rats.

The influence of sex in determining responses to opioid analgesics has been well established in rodents and monkeys in assays of short-lasting, phasic pain. The purpose of this investigation was to use a capsaicin model of tonic pain to evaluate sex differences in hyperalgesia and mu-opioid-induced antihyperalgesia in Fischer 344 (F344) rats. Capsaicin injected into the tail produced a dose-dependent thermal hyperalgesia in males and females, with the dose required to produce a comparable level of hyperalgesia being 3.

Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.

The use of irreversible antagonists to assess opioid efficacy has proven fruitful for classifying opioids on the basis of high or low efficacy, but few studies have provided quantitative estimates of efficacy. The purpose of this study was to use beta-funaltrexamine (beta-FNA) and clocinnamox (C-CAM) in a drug discrimination procedure to examine the efficacy of fentanyl, morphine, l-methadone, sufentanil, and etorphine. In pigeons trained to discriminate 0.

Sex-related differences in mechanical nociception and antinociception produced by mu- and kappa-opioid receptor agonists in rats.

Previous studies indicate that in antinociceptive procedures employing thermal, chemical and electrical stimuli, opioids are generally more potent in male than female rodents. The purpose of the present study was to examine nociception and opioid antinociception in male and female rats using a mechanical nociceptive stimulus. Results indicated that males had a higher threshold for nociception, and in tests in which a constant pressure was applied to the hindpaw, the paw withdrawal latencies were consistently longer in males.