Publications by authors named "Eric Rosenthal"

Background: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical repair.

View Article and Find Full Text PDF

Objectives: Septic shock is a common condition necessitating timely management including hemodynamic support with vasopressors. Despite the high prevalence and mortality, there is limited data characterizing patients who require three or more vasopressors. We sought to define the demographics, outcomes, and prognostic determinants associated with septic shock requiring three or more vasopressors.

View Article and Find Full Text PDF

Background: Covered stent correction (CSC) of a superior sinus venosus atrial septal defect is an alternative to surgery in selected patients, but anatomic variation means that assessment for CSC requires a 3-dimensional anatomic understanding. Heart VR is a virtual reality (VR) system that rapidly displays and renders multimodality imaging without prior image segmentation. The aim of this study was to evaluate the performance of the Heart VR system to assess patient suitability for CSC.

View Article and Find Full Text PDF
Article Synopsis
  • - Atrioventricular block is a common issue in adults with congenital heart disease, making pacemaker implantation difficult, thus highlighting the importance of atrioventricular synchronous pacing for improved blood flow.
  • - A 25-year-old male with a history of complex heart surgeries experienced heart block and had a malfunctioning pacemaker before receiving a dual-chamber leadless pacemaker, which successfully restored his heart's rhythmic function.
  • - This case represents a valuable addition to the management options for patients with complex congenital heart diseases, showcasing the effectiveness of leadless pacemakers in ensuring atrioventricular synchrony.
View Article and Find Full Text PDF

Alpha (8-12 Hz) frequency band oscillations are among the most informative features in electroencephalographic (EEG) assessment of patients with disorders of consciousness (DoC). Because interareal alpha synchrony is thought to facilitate long-range communication in healthy brains, coherence measures of resting-state alpha oscillations may provide insights into a patient's capacity for higher-order cognition beyond channel-wise estimates of alpha power. In multi-channel EEG, global coherence methods may be used to augment standard spectral analysis methods by both estimating the strength and identifying the structure of coherent oscillatory networks.

View Article and Find Full Text PDF
Article Synopsis
  • Research highlights that the accuracy of clinical prognoses for survival after moderate to severe traumatic brain injury (TBI) is crucial since many patients die due to withdrawal of life-sustaining therapy based on assumed poor outcomes.
  • The study's objective was to evaluate if the automated measurement of cerebral contusion size and location can enhance the IMPACT score, a current prognostic model that doesn’t account for where brain injuries occur.
  • Conducted in 18 US trauma centers, the study assessed adult patients with moderate or severe TBI using an AI tool, BLAST-CT, to analyze CT scans, focusing on how contusion characteristics relate to long-term recovery outcomes using tools like the Glasgow Outcome Scale.
View Article and Find Full Text PDF
Article Synopsis
  • The study looked at how doctors sedate patients with serious brain injuries to help reduce pressure in the brain, known as intracranial pressure (ICP).
  • Researchers analyzed data from a group of patients who were in the ICU for at least five days and had their sedation levels tracked daily.
  • They found that the highest sedation levels were given on the first day in the ICU, but the way sedation was managed varied a lot between different hospitals.
View Article and Find Full Text PDF

Background & Aims: In France, bulevirtide (BLV) became available in September 2019 through an early access program to treat patients with HDV. The aim of this analysis was to evaluate the efficacy and safety of BLV in patients with HIV and HDV coinfection.

Methods: Patients received BLV 2 mg ± pegylated interferon-α (pegIFNα) according to the physician's decision.

View Article and Find Full Text PDF

Importance: Treatment for intracranial pressure (ICP) has been increasingly informed by machine learning (ML)-derived ICP waveform characteristics. There are gaps, however, in understanding how ICP monitor type may bias waveform characteristics used for these predictive tools since differences between external ventricular drain (EVD) and intraparenchymal monitor (IPM)-derived waveforms have not been well accounted for.

Objectives: We sought to develop a proof-of-concept ML model differentiating ICP waveforms originating from an EVD or IPM.

View Article and Find Full Text PDF

Background/objectives: Epileptiform activity (EA), including seizures and periodic patterns, worsens outcomes in patients with acute brain injuries (e.g., aneurysmal subarachnoid hemorrhage [aSAH]).

View Article and Find Full Text PDF

Background: Social determinants of health (SDOH) have been linked to neurocritical care outcomes. We sought to examine the extent to which SDOH explain differences in decisions regarding life-sustaining therapy, a key outcome determinant. We specifically investigated the association of a patient's home geography, individual-level SDOH, and neighborhood-level SDOH with subsequent early limitation of life-sustaining therapy (eLLST) and early withdrawal of life-sustaining therapy (eWLST), adjusting for admission severity.

View Article and Find Full Text PDF

Ablation of accessory pathways in patients with Ebstein's anomaly can be challenging. Despite increasing experience and advances in mapping technology, success is limited and recurrence rates can be high. To date, high-density electroanatomic mapping has not been studied in this anatomical substrate.

View Article and Find Full Text PDF

Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited.

Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to investigate the long-term safety of methylphenidate (MPH), particularly regarding its impact on pubertal maturation and bone age.
  • Participants from a two-year observational study were compared across three groups: those on MPH, those not on MPH, and a control group without ADHD.
  • Results showed no differences in sexual maturation between medicated and unmedicated ADHD groups, and while there was slight bone maturation acceleration in the medicated group, their predicted adult height remained stable, indicating no long-term safety concerns with MPH.
View Article and Find Full Text PDF

Neuroprognostication following acute brain injury (ABI) is a complex process that involves integrating vast amounts of information to predict a patient's likely trajectory of neurologic recovery. In this setting, critically evaluating salient ethical questions is imperative, and the implications often inform high-stakes conversations about the continuation, limitation, or withdrawal of life-sustaining therapy. While neuroprognostication is central to these clinical "life-or-death" decisions, the ethical underpinnings of neuroprognostication itself have been underexplored for patients with ABI.

View Article and Find Full Text PDF

Early prediction of the recovery of consciousness in comatose cardiac arrest patients remains challenging. We prospectively studied task-relevant fMRI responses in 19 comatose cardiac arrest patients and five healthy controls to assess the fMRI's utility for neuroprognostication. Tasks involved instrumental music listening, forward and backward language listening, and motor imagery.

View Article and Find Full Text PDF

Objectives: Epileptiform activity (EA) worsens outcomes in patients with acute brain injuries (e.g., aneurysmal subarachnoid hemorrhage [aSAH]).

View Article and Find Full Text PDF