Publications by authors named "Eric Robert Strieter"
Article Synopsis
- The study investigates the deregulation of the E6AP ubiquitin ligase's role in cervical tumors and neurodevelopmental disorders, focusing on its activity and specificity.
- Researchers detail how specific structural features of E6AP interact with ubiquitin during different catalytic steps, particularly highlighting a crucial interface for thioester formation.
- They reveal important regions in both E6AP and ubiquitin that influence the formation of isopeptide bonds, noting that specific mutations can alter linkage types and suggesting a common mechanism in ubiquitin chain assembly for various ubiquitination enzymes.
