Publications by authors named "Eric Olle"
Objective: The goal of this work was to develop robust techniques for the processing and identification of SUA using artificial intelligence (AI) image classification models.
Methods: Ultrasound images obtained retrospectively were analyzed for blinding, text removal, AI training, and image prediction. After developing and testing text removal methods, a small n-size study (40 images) using fastai/PyTorch to classify umbilical cord images.
Article Synopsis
- Wegener's Granulomatosis (WG) is an autoimmune condition that mainly impacts small blood vessels, leading to kidney and lung issues.
- The study aimed to create an antibody array to analyze protein expression in the serum of WG patients compared to healthy individuals, focusing on those that are age and sex matched.
- The results showed significant increases in 24 proteins related to vascular injury in WG patients, suggesting potential biomarkers for better understanding and diagnosing the disease.
Article Synopsis
- Scientists wanted to find out how a substance called interleukin-6 (IL-6) affects a type of disease called granulomatous vasculitis.
- They used two groups of mice: one group that had IL-6 and one that didn’t, and they injected them with a substance from yeast to see how their bodies reacted.
- The results showed that both groups had similar numbers of immune cells and problems in their lungs, suggesting that IL-6 might help a little but isn't super important for the development of this disease.
Article Synopsis
- Previous research indicated that Interleukin-6 (IL-6) might be a marker for vasculitis, prompting further investigation into its role in immune complex-induced vascular injury models with both IL-6 deficient and sufficient mice.
- Elevated IL-6 levels were found in the plasma of injured IL-6 sufficient mice with acute conditions, while IL-6 deficient mice displayed low or undetectable levels.
- Despite the differences in IL-6 levels, histological analyses showed no significant variation in vascular injury, permeability, or immune cell influx between the IL-6 deficient and sufficient groups, suggesting that IL-6 is not critical for the vascular inflammatory response.
Article Synopsis
- A partial hepatectomy, which means removing part of the liver, starts a healing process in the liver that involves cell growth and changes in the liver's structure.
- Researchers studied the role of a protein called MMP-9 in helping the liver heal after this surgery using special mice.
- They found that mice without MMP-9 healed more slowly and had less important molecules for healing, like VEGF, than normal mice.
Changes in circulating cytokines might serve as predictors of compound-evoked inflammatory responses. CD-1 mice were treated with lipopolysaccharide (LPS; 0.2 ml of 0.
View Article and Find Full Text PDFAntibody microarrays are a high-throughput proteomic technology used to examine the expression of multiple proteins in complex solutions. Antibody microarrays can be manufactured on a variety of commercially available activated glass or coated slides. The goal of this study was to compare Hydrogeltrade mark, nitrocellulose, aldehyde-silane and epoxy-silane slides to determine the amount of antibody bound.
View Article and Find Full Text PDFAntibody microarrays are a high throughput technology used to concurrently screen for protein expression. Most antibody arrays currently used are based on the ELISA sandwich approach that uses two antibodies to screen for the expression of a limited number of proteins. Also because antigen-antibody interactions are concentration-dependent, antibody microarrays need to normalize the amount of antibody that is used.
View Article and Find Full Text PDFThe current studies demonstrate protective and harmful effects of neutrophils (PMN) during experimental sepsis after cecal ligation and puncture (CLP). It is known that CLP induces signaling defects in blood PMN. When PMN were depleted 12 h after CLP, there were dramatic reductions in levels of bacteremia, evidence for reduced liver and renal dysfunction, sharp reductions in serum levels of cytokines (IL-1beta, IL-6, IL-10, TNF-alpha, and IL-2), and improved survival.
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