Cognitive functioning in untreated glioma patients: The limited predictive value of clinical variables.

Background: Previous research identified many clinical variables that are significantly related to cognitive functioning before surgery. It is not clear whether such variables enable accurate prediction for individual patients' cognitive functioning because statistical significance does not guarantee predictive value. Previous studies did not test how well cognitive functioning can be predicted for (yet) untested patients.

Development and external validation of a predictive model for pathological complete response of rectal cancer patients including sequential PET-CT imaging.

Purpose: To develop and validate an accurate predictive model and a nomogram for pathologic complete response (pCR) after chemoradiotherapy (CRT) for rectal cancer based on clinical and sequential PET-CT data. Accurate prediction could enable more individualised surgical approaches, including less extensive resection or even a wait-and-see policy.

Methods And Materials: Population based databases from 953 patients were collected from four different institutes and divided into three groups: clinical factors (training: 677 patients, validation: 85 patients), pre-CRT PET-CT (training: 114 patients, validation: 37 patients) and post-CRT PET-CT (training: 107 patients, validation: 55 patients).

Non-parametric algorithmic generation of neuronal morphologies.

Generation algorithms allow for the generation of Virtual Neurons (VNs) from a small set of morphological properties. The set describes the morphological properties of real neurons in terms of statistical descriptors such as the number of branches and segment lengths (among others). The majority of reconstruction algorithms use the observed properties to estimate the parameters of a priori fixed probability distributions in order to construct statistical descriptors that fit well with the observed data.

Modeling recognition memory using the similarity structure of natural input.

The natural input memory (NIM) model is a new model for recognition memory that operates on natural visual input. A biologically informed perceptual preprocessing method takes local samples (eye fixations) from a natural image and translates these into a feature-vector representation. During recognition, the model compares incoming preprocessed natural input to stored representations.

SCAN: A Scalable Model of Attentional Selection.

This paper describes the SCAN (Signal Channelling Attentional Network) model, a scalable neural network model for attentional scanning. The building block of SCAN is a gating lattice, a sparsely-connected neural network defined as a special case of the Ising lattice from statistical mechanics. The process of spatial selection through covert attention is interpreted as a biological solution to the problem of translation-invariant pattern processing.