Publications by authors named "Eric N Pederson"
Article Synopsis
- Pancreatic cancer cells utilize various molecular mechanisms to boost protein synthesis, which aids tumor growth, and this study investigates the impact of the mTOR inhibitor rapamycin on mRNA translation.
- Rapamycin inhibits the translation of specific mRNAs related to cancer growth while also revealing that mTOR inhibition activates feedback mechanisms, including the upregulation of kinases that enhance translation.
- Combining rapamycin with eIF4A inhibitors shows significant growth inhibition in pancreatic cancer cells, suggesting that targeting the translation processes downstream of mTOR could provide a promising therapeutic approach for treating this type of cancer.
Upon activation, fibrinogen is converted to insoluble fibrin, which assembles into long strings called protofibrils. These aggregate laterally to form a fibrin matrix that stabilizes a blood clot. Lateral aggregation of protofibrils is mediated by the αC domain, a partially structured fragment located in a disordered region of fibrinogen.
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