Steroid-Resistant Nephrotic Syndrome-Associated Mutations Have Differential Effects on Myosin 1e Localization, Dynamics, and Activity.

Background: Myo1e is a nonmuscle motor protein enriched in podocytes. Mutations in are associated with steroid-resistant nephrotic syndrome (SRNS). Most of the variants identified by genomic sequencing have not been functionally characterized.

Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro.

Introduction: The prevalence of impaired cutaneous wound healing is high and treatment is difficult and often ineffective, leading to negative social and economic impacts for our society. Innovative treatments to improve cutaneous wound healing by promoting complete tissue regeneration are therefore urgently needed. Mesenchymal stromal cells (MSCs) have been reported to provide paracrine signals that promote wound healing, but (i) how they exert their effects on target cells is unclear and (ii) a suitable delivery system to supply these MSC-derived secreted factors in a controlled and safe way is unavailable.