Simulations of Test Reduction Using Pooled Heavy Metals Analysis in Cannabis.

Background: Cannabis species have a propensity to bioaccumulate toxic heavy metals from their growth media. Increased testing for these metals is required to improve the safety of the legal medical and recreational cannabis industries. However, the current methods used for mandated heavy metals tests are not efficient for a large framework.

Step-by-step real time monitoring of a catalytic amination reaction.

The multiple reaction monitoring mode of a triple quadrupole mass spectrometer is used to examine the Buchwald-Hartwig amination reaction at 0.1% catalyst loading in real-time using sequential addition of reagents to probe the individual steps in the cycle. This is a powerful new method for probing reactions under realistic conditions.

Correction: Synthesis of polyoxometalate clusters using carbohydrates as reducing agents leads to isomer-selection.

Correction for 'Synthesis of polyoxometalate clusters using carbohydrates as reducing agents leads to isomer-selection' by Eric Janusson et al., Chem. Commun.

Synthesis of polyoxometalate clusters using carbohydrates as reducing agents leads to isomer-selection.

By using sugars as the reducing agents, we demonstrate that it is possible to control the self-assembly of polyoxomolybdates through selective preparation of a single heteropolyanion isomer. d-(-)-Fructose has been proved to be an effective reducing sugar compared to the chemically similar carbohydrate d-(+)-glucose. The gentle reduction results in favourable formation of the Wells-Dawson type gamma isomer in 6-fold reduced form at room temperature.

Phenol-selective mass spectrometric analysis of jet fuel.

Bromobenzyl compounds react selectively with phenols via the Williamson ether synthesis. An imidazolium charge-tagged bromobenzyl compound can be used to reveal phenol impurities in jet fuel by analysis via electrospray ionization mass spectrometry. The complex matrix as revealed by Cold EI GC/MS analysis is reduced to a few simple sets of compounds in the charge-tagged ESI mass spectrum, primarily substituted phenols and thiols.

Real-time analysis of Pd(dba) activation by phosphine ligands.

A combination of UV-Vis spectroscopy and electrospray ionization mass spectrometry is used for real-time monitoring of Pd(dba) activation with sulfonated versions of PPh and Buchwald-type ligands. This provides insight into the effect of ligand and preparation conditions on activation and allows for establishment of rational activation protocols.

Selective mass spectrometric analysis of thiols using charge-tagged disulfides.

A simple chemical derivatization technique was developed for electrospray ionization mass spectrometry (ESI-MS) in which thiols and disulfides may be selectively analyzed in a complex matrix and easily characterized. These reagents enhance detection of thiols and disulfides solely due to the nature of the charge-tag derivatization agent and therefore does not require an isotopically labelled substrate. The charged disulfides readily and exclusively react with thiols in a complex matrix in a short amount of time.