Publications by authors named "Eric H Souied"
Purpose: To report 8 cases of acute intra ocular inflammation (IOI) following intravitreal injections (IVI) of faricimab in patients with age related macular degeneration (AMD), retinal vein occlusion (RVO) and macular neovascularization associated with chronic central serous retinopathy (CSR).
Methods: This is a multicentric retrospective observational case-series. Cases of acute IOI that occurred in 5 different institutions in France and Italy between November 2023 and June 2024 were reported.
To review the evolution of terminology describing the classification of lesions in neovascular age-related macular degeneration (nAMD) based on retinal imaging technologies. A review of the current and historical literature on imaging-guided classification of neovascularization in nAMD was performed. Imaging-guided classification of neovascularization in nAMD facilitates understanding of the pathological mechanisms and disease progression.
View Article and Find Full Text PDFMacular telangiectasia type 2 in a patient with Down syndrome: A possible association.
Am J Ophthalmol Case Rep
December 2024
Purpose: Down syndrome (DS) is one of the most prevalent genetic diseases associated with a variety of ophthalmic disorders, including reported retinal abnormalities. Macular telangiectasia type 2 (MacTel 2) is a late-onset neurodegenerative retinal disease with a substantial genetic component. We hereby describe a case of a female with DS who presented with MacTel 2, and we discuss the possible pathways associating both entities.
View Article and Find Full Text PDFPurpose: To assess the sensitivity and specificity of the "triple layer sign" (TLS) (retinal pigment epithelium (RPE), neovascular tissue, and Bruch's membrane) on structural optical coherence tomography (OCT) images for the diagnosis of treatment-naïve non-exudative type-1 macular neovascularization (NE-MNV) in age-related macular degeneration (AMD).
Design: Cross-sectional study.
Methods: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.
Article Synopsis
- This study focused on characterizing a specific condition called LeptoVitelliform Maculopathy (LVM), which is associated with diffuse choroidal thinning and reticular pseudodrusen, comparing it to other acquired vitelliform lesions (AVL).
- The research involved 56 patients, analyzing differences in lesion size, visual impairment, and structural features like the external limiting membrane and choroidal vascular index.
- Results showed that LVM patients were older, had smaller lesions, and displayed significant structural changes, suggesting that LVM represents a unique phenotype that requires further investigation for prognostic implications.
Objective: To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid.
Design: Retrospective, cohort study.
Subjects: The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectrum.
Article Synopsis
- The study aims to develop a deep learning model to automatically predict late recurrence of rhegmatogenous retinal detachment using ultra-wide field images.
- Researchers analyzed data from patients over 18 who underwent surgery for retinal detachment, training four different models on preoperative and postoperative images.
- The models achieved high accuracy rates (up to 91.1%) in predicting recurrence, highlighting potential risk factors like extensive laser retinopexy and asymmetrical staphyloma.
Objective: To assess the effectiveness and safety of a rigorous short-term supine position in preventing inadvertent retinal displacement after pars plana vitrectomy (PPV) with gas tamponade for rhegmatogenous retinal detachment (RRD).
Methods: We conducted a retrospective observational analysis of a case series at two ophthalmological surgical centers. We included eyes diagnosed with macula-off RRD that maintained a strict face-up position for three hours immediately after PPV with intraoperative perfluorocarbon liquid (PFCL) and 20% sulfur hexafluoride (SF6) tamponade.
Purpose: To report three cases of hemorrhagic unilateral retinopathy, diagnosed by multimodal imaging.
Methods: Case report of 3 patients, 2 women and one man, aged 51, 74, and 52, respectively.
Results: Symptoms were acute floaters, blurred vision, or central scotoma, unilateral in all cases.
Purpose: To compare photoreceptor density automated quantification in eyes with subretinal drusenoid deposits (SDD) and healthy controls using Heidelberg Spectralis High Magnification Module (HMM) imaging.
Methods: Twelve eyes of 6 patients with intermediate AMD, presenting with SDD were included, as well as twelve eyes of healthy controls. Individual dot SDD within the central 30° retina were examined with infrared confocal laser ophthalmoscopy, HMM, and spectral-domain optical coherence tomography (SD-OCT).
Article Synopsis
- The study aims to describe acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using various multimodal imaging techniques, specifically focusing on retro-mode imaging.
- A young male patient with APMPPE underwent multiple examinations, including visual acuity tests and advanced imaging methods like Optical Coherence Tomography (OCT) and fluorescein angiography, being monitored for two months.
- Results showed normal visual acuity and the identification of characteristic lesions, with retro-mode imaging revealing detailed lesion characteristics that corresponded to findings in angiography, establishing its role as a helpful non-invasive tool in APMPPE.
Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaining novel insight into the intersection of treatment regimens, decisions, anatomic outcomes, and vision.
Design: Primary data collection, noninterventional, prospective, multinational, multicenter clinical practice study.
Background: To describe the occurrence of nonexudative intraretinal fluid (IRF) in intermediate age-related macular degeneration.
Methods: A retrospective study was designed to include consecutive cases with intermediate age-related macular degeneration associated with IRF. A multimodal imaging approach was used to confirm diagnosis of IRF in intermediate age-related macular degeneration.
Article Synopsis
- The study aimed to analyze the challenges in diagnosing a 56-year-old woman with early symptoms of late-onset retinal degeneration (L-ORD) over an eleven-year follow-up period, stressing the importance of electrophysiological tests for detecting inherited retinal diseases.
- Initially, she was misdiagnosed with fundus albipunctatus, but after a decade, tests showed deterioration in rod and cone responses, prompting further genetic testing.
- Ultimately, genetic results confirmed the diagnosis of L-ORD linked to a variation in the C1QTNF5 gene, highlighting the need for careful monitoring and diagnostic follow-ups in such cases.
Article Synopsis
- - An AI-based deep learning classifier was developed to help doctors differentiate between age-related geographic atrophy and extensive macular atrophy with pseudodrusen-like appearance using fundus autofluorescence (FAF) images.
- - The study involved 300 patients, with the classifiers trained on high-quality FAF images and evaluated on a separate set; the 30° FAF classifier had a sensitivity of 84.6% and specificity of 85.3%, while the 55° FAF classifier performed even better with 90% sensitivity and 84.6% specificity.
- - Results indicate that artificial intelligence can effectively distinguish between atrophy linked to AMD and EMAP, with better performance observed using wider field FAF images.
The Impact of Diabetic Retinopathy on the Choriocapillaris in Neovascular AMD.
Invest Ophthalmol Vis Sci
November 2023
Purpose: To investigate the impact of diabetic retinopathy (DR) on morphological choriocapillaris (CC) modifications in eyes with type 1 macular neovascularization (MNV) secondary to AMD using optical coherence tomography angiography (OCTA).
Methods: Eyes with AMD-related type 1 MNV with and without DR were prospectively included. We performed 3 × 3 mm OCTA scans at two visits: before the loading phase of intravitreal injections of aflibercept (T1) and 1 month after the last injection (T2).
Aim: We describe a report of three cases of bilateral Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS), their respective multimodal imaging, and retinal nerve fiber layer (RNFL) analysis over time.
Methods: We performed an elaborated multimodal imaging of three pediatric patients with PHOMS. We performed a visual acuity testing, followed by a biomicroscopic and fundus examination, an additional Optical Coherence Tomography (OCT), fundus autofluorescence (FAF), infra-red (IR), fluorescein angiography (FA), Scanning laser Ophtalmoscopy (SLO), and retro-mode imaging.
Objective: To analyze the progression of macular atrophy in Fundus Flavimaculatus (FFM) versus Extensive Macular Atrophy with Pseudo-drusen (EMAP), using Spectralis® RegionFinder™ tool.
Methods: Retrospective review of patients diagnosed with FFM and EMAP. Ophthalmic imaging features were reviewed by retina specialists for each patient in both eyes.
Article Synopsis
- The study investigates how hemodialysis (HD) affects the retinal and choroidal blood vessels in patients with end-stage kidney disease (ESKD) using advanced imaging techniques.
- Results showed a significant decrease in subfoveal choroidal thickness (SCT) and an increase in non-perfusion of the choriocapillaris after HD, while retinal vascular density remained unchanged.
- A higher level of B-Nitric Peptide (BNP) before HD was correlated with a greater decrease in SCT, suggesting a link between this biomarker and choroidal health in ESKD patients undergoing dialysis.
Purpose: To the describe OCT imaging characteristics of a cohort of patients showing spontaneously closing degenerative or mixed type lamellar macular holes (LMH) and to compare them to the ones of a sex and age matched group showing stable lesions.
Methods: Patients diagnosed with degenerative and mixed type LMHs showing OCT-documented spontaneous anatomical closure were retrospectively selected from 3 specialized retina centres. An equal number of age and sex matching subjects were randomly selected among patients with anatomically stable lesions.
Purpose: To describe multimodal imaging of two cases of bilateral non-vascularized pigment epithelial detachments (PED) in young patients with a long-term follow-up.
Methods: A complete ophthalmological examination was performed at each follow-up visit including best corrected visual acuity (BCVA), intraocular pressure, slit lamp examination, spectral domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography, OCT angiography.
Results: Multimodal imaging of two women presenting avascular PED, aged 43 and 57, respectively, was described.
Purpose: To analyze differences in refractive outcome Δ (difference between postoperative and expected refractive error) and in anterior segment changes between cataract surgery patients and combined phacovitrectomy patients. We also aimed to provide a corrective formula allowing to minimise the refractive outcome Δ in combined surgery patients.
Methods: Candidates for phacoemulsification and combined phacovitrectomy (respectively PHACO and COMBINED groups) were prospectively enrolled in two specialised centres.