Adapting a Neural Engineering Summer Camp for High School Students to a Fully Online Experience.

The COVID-19 pandemic and its resulting health and safety concerns caused the cancellation of many engineering education opportunities for high school students. To expose high school students to the field of neural engineering and encourage them to pursue academic pathways in biomedical engineering, the Center for Neurotechnology (CNT) at the University of Washington converted an in-person summer camp to a fully online program (Virtual REACH Program, VRP) offering both synchronous and asynchronous resources. The VRP is a five-day online program that focuses on a different daily theme (neuroscience, brain-computer interfaces, electrical stimulation, neuroethics, career/academic pathways).

Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imaging.

Planarian flatworms are known as the masters of regeneration, re-growing an entire organism from as little as 1/279th part of their body. While the proteomics of these processes has been studied extensively, the planarian lipodome remains relatively unknown. In this study we investigate the lipid profile of planarian tissue sections with imaging Time-of-Flight - Secondary-Ion-Mass-Spectrometry (ToF-SIMS).

Online Teaching Resources about Medicinal Plants and Ethnobotany.

Classroom exploration of plant-based medicines and ethnobotany is a timely and valuable way to engage students in science. This highlights Internet-based resources to help teachers in primary and secondary classrooms incorporate lessons and activities to teach about plant medicines.

New Perspectives on Neuroengineering and Neurotechnologies: NSF-DFG Workshop Report.

Goal: To identify and overcome barriers to creating new neurotechnologies capable of restoring both motor and sensory function in individuals with neurological conditions.

Methods: This report builds upon the outcomes of a joint workshop between the US National Science Foundation and the German Research Foundation on New Perspectives in Neuroengineering and Neurotechnology convened in Arlington, VA, USA, November 13-14, 2014.

Results: The participants identified key technological challenges for recording and manipulating neural activity, decoding, and interpreting brain data in the presence of plasticity, and early considerations of ethical and social issues pertinent to the adoption of neurotechnologies.

Brains-Computers-Machines: Neural Engineering in Science Classrooms.

Neural engineering is an emerging field of high relevance to students, teachers, and the general public. This Feature presents online resources that educators and scientists can use to introduce students to neural engineering and to integrate core ideas from the life sciences, physical sciences, social sciences, computer science, and engineering into the classroom.

Explain the brain: websites to help scientists teach neuroscience to the general public.

Increased public awareness of neuroscience often results in requests to neuroscientists to share their knowledge with lay audiences. This Feature showcases Internet-based resources to help neuroscientists explain their work to the general public and K–12 audiences.

A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging.

The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects.

Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine.

The basal ganglia are involved not only with motor processes such as posture, pre-movement planning and movement initiation, but also with the processing and modulation of nociceptive somatosensory information. In the current studies, unilateral, intrastriatal 6-hydroxydopamine (6-OHDA) was used to investigate how dopamine depletion alters nociceptive behavioral responses to chemical, thermal and mechanical stimulation in rats. Compared to control rats injected with intrastriatal saline, rats depleted of dopamine displayed increased nociceptive responses to chemical stimulation of the face and hyperalgesic responses to thermal stimulation of the hind paw without alterations in rearing behavior or body weight gain.

Behavioural responses following tooth injury in rats.

Early changes in spontaneous behaviour (exploration, grooming, freezing, rearing, jaw motion, yawning) and body weight were measured at two and three days after pulp exposure injury and implantation of Fluorogold (FG) into molar teeth of rats. Rats with FG and injuries to three teeth gained weight less rapidly, explored less frequently and froze more often than sham-operated rats. Yawning was not observed in any rats prior to surgery and it was seen more frequently in tooth-injured rats than in sham-operated rats.

Behavioral and electrophysiological consequences of deafferentation following chronic constriction of the infraorbital nerve in adult rats.

Deafferentation of the hind paw following sciatic nerve injury results in behavioral changes, such as autotomy, suggestive of persistent, spontaneous pain. The effects of deafferentation involving trigeminal nerves have, however, received less attention. Here, alterations in trigeminal ganglion neuronal activity and mechanically evoked and spontaneous behavior were studied in adult rats after a chronic constriction injury of the infraorbital nerve (ION).

Trigeminal ganglion neuronal activity and glial fibrillary acidic protein immunoreactivity after inferior alveolar nerve crush in the adult rat.

Nerve injury to the mandibular division of the trigeminal nerve has been shown to cause satellite cell reactions that extend beyond the mandibular division of the trigeminal ganglion into the maxillary and ophthalmic divisions. The goal of this study was to determine whether any physiological abnormalities correlated with this dispersal of satellite cell reaction. We investigated the electrophysiological and satellite cell glial fibrillary acidic protein immunoreactivity (GFAP-IR) changes that occur within the trigeminal ganglion 3, 10 and 59 days after a crush injury of the inferior alveolar nerve (IAN).

The role of the basal ganglia in nociception and pain.

The involvement of the basal ganglia in motor functions has been well studied. Recent neurophysiological, clinical and behavioral experiments indicate that the basal ganglia also process non-noxious and noxious somatosensory information. However, the functional significance of somatosensory information processing within the basal ganglia is not well understood.

Tooth pulp-evoked potentials in the monkey: cortical surface and intracortical distribution.

The distribution of tooth pulp-evoked potentials (TPEPs) was characterized in the primary motor (MI), primary somatosensory (SI) and secondary somatosensory (SII) cortices of the monkey. Bipolar electrical tooth pulp stimulation elicited TPEP components P23 and N44 over SI, P26 and N72 over MI, and P72, N161, P280, N420, P561 and N662 over SII. Muscular artifacts and extradental input did not affect the TPEP as demonstrated by experiments using a neuromuscular blocking agent and removal of the pulp, respectively.

Neuroma pain model: correlation of motor behavior and body weight with autotomy in rats.

A rat pain model was investigated by examining the correlation of autotomy (self-mutilation) score with motor behavior and body weight change after sciatic nerve transection, encapsulation and neuroma formation. Observations of motor behavior and body weight changes (e.g.