Publications by authors named "Eric G Stokes"
Article Synopsis
- High mechanical loading induces temporary disruptions in cell membranes (PMD) that initiate a process called mechanotransduction, which is essential for bone adaptation.
- The study hypothesized that disrupting a protein called β2-spectrin (Sptbn1), which supports cell structure, would increase membrane fragility, leading to altered responses in osteocytes (bone cells) under mechanical stress.
- Results showed that disrupting Sptbn1 led to more PMD formation and slower repair rates in cells, impaired cell survival, and reduced bone thickening in response to mechanical loading, highlighting Sptbn1's crucial role in bone adaptation and cell response to stress.
α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the elaborate extracellular sequences of α-neurexins contribute to synapse function is poorly understood. We recently characterized the presynaptic gain-of-function phenotype caused by a missense mutation in an evolutionarily conserved extracellular sequence of neurexin-3α (A687T) that we identified in a patient diagnosed with profound intellectual disability and epilepsy.
View Article and Find Full Text PDF