Controlled release of basic fibroblast growth factor for angiogenesis using acoustically-responsive scaffolds.

The clinical translation of pro-angiogenic growth factors for treatment of vascular disease has remained a challenge due to safety and efficacy concerns. Various approaches have been used to design spatiotemporally-controlled delivery systems for growth factors in order to recapitulate aspects of endogenous signaling and thus assist in translation. We have developed acoustically-responsive scaffolds (ARSs), which are fibrin scaffolds doped with a payload-containing, sonosensitive emulsion.

In vitro and in vivo assessment of controlled release and degradation of acoustically responsive scaffolds.

Unlabelled: Spatiotemporally controlled release of growth factors (GFs) is critical for regenerative processes such as angiogenesis. A common strategy is to encapsulate the GF within hydrogels, with release being controlled via diffusion and/or gel degradation (i.e.

In Situ Transfection by Controlled Release of Lipoplexes Using Acoustic Droplet Vaporization.

Localized delivery of nucleic acids to target sites (e.g., diseased tissue) is critical for safe and efficacious gene therapy.