Publications by authors named "Eric D Bernstein"
Article Synopsis
- Cigarette smoke contains various toxins and carcinogens, many of which are not fully studied.
- Aqueous cigarette smoke extract (CSE) is prepared by bubbling cigarette smoke through mammalian cell culture medium, and the type of pipette used significantly affects its toxicity.
- The findings highlight the need for standardization in CSE preparation methods to improve the comparability and accuracy of research results.
Pulmonary blastoma is a rare lung cancer classified into three subtypes: classic biphasic pulmonary blastoma (CBPB), well-differentiated fetal adenocarcinoma (WDFA), and pleuropulmonary blastoma (PPB) of childhood. Compared to the other subtypes, CPPB is an aggressive tumor with an overall five-year survival of 16% across all stages. We present two cases of biopsy-proven metastatic CBPB, who have been disease-free for over 10 years since treatment completion.
View Article and Find Full Text PDFIntroduction: Regardless of epidermal growth factor receptor (EGFR) mutation status, erlotinib improves survival for patients with advanced non-small cell lung cancer (NSCLC) after one or more chemotherapy regimens. Enzastaurin is an oral serine/threonine kinase inhibitor. This phase II study was designed to evaluate the efficacy and safety of erlotinib and enzastaurin in NSCLC, a combination with promise to overcome EGFR resistance based on preclinical models.
View Article and Find Full Text PDFArticle Synopsis
- Surgical resection is the primary treatment for early-stage non-small-cell lung cancer, providing the best chance for a cure, but has high recurrence rates when used alone.
- Recent studies, including a meta-analysis and four randomized trials, support the use of adjuvant platinum-based chemotherapy to reduce these recurrence rates.
- Adjuvant chemotherapy can improve 5-year survival rates by about 5%-15%, making it the recommended treatment following surgical resection for patients with completely removed tumors in stages I, II, and IIIA.