Treatment of mild, moderate, and severe onychomycosis using 870- and 930-nm light exposure.

Background: The Noveon is a unique dual-wavelength near-infrared diode laser used to treat onychomycosis. The device operates at physiologic temperatures that are thermally safe for human tissue. It uses only 870- and 930-nm near-infrared light, wavelengths that have unique photolethal effects on fungal pathogens.

Photodamage to multidrug-resistant gram-positive and gram-negative bacteria by 870 nm/930 nm light potentiates erythromycin, tetracycline and ciprofloxacin.

We have previously shown that 870 nm/930 nm wavelengths cause photodamage at physiologic temperatures in methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli via generation of endogenous radical oxygen species (ROS) and decreased plasma membrane potentials (Delta Psi p). We tested MRSA (Strain HSJ216) in vitro with sublethal 870 nm/930 nm laser energy and subinhibitory concentrations of erythromycin, tetracycline, penicillin, rifampin and trimethoprim to surmise whether photodamage could potentiate these antimicrobials. We also tested patient isolates of fluoroquinolone-resistant MRSA and E.

Near-infrared photoinactivation of bacteria and fungi at physiologic temperatures.

We examined a laser system (870 and 930 nm), employing wavelengths that have exhibited cellular photodamage properties in optical traps. In vitro, with 1.5 cm diameter flat-top projections (power density of 5.

A review of current research in light-based technologies for treatment of podiatric infectious disease states.

Recently, there has been a resurgence of interest in potential phototherapy technologies for the local treatment of bacterial and fungal infection. Currently, onychomycosis is the principle disease that is the target of these phototherapies in podiatric medicine. Some of these technologies are currently undergoing in vitro and in vivo trials approved by institutional review boards.

Why wavelength and delivery systems are the most important factors in using a dental hard-tissue laser: a literature review.

Various lasers have been investigated in the dental clinic as an alternative to the dental drill for the treatment of dental hard tissues. Among the lasers, the erbium-based solid-state infrared lasers, operating at approximately 3 microm, have demonstrated they are effective in dental applications because of their high affinity for water in the hydroxyapatite of the tooth structure. Water is the dominant chromophore that absorbs the laser energy during hard-tissue treatment; this leads to well-established, mechanical, thermally driven, and explosive ablation, which is the basis for the erbium laser-tissue interaction.