Publications by authors named "Eric Bertandeau"
Article Synopsis
- Rituximab has shown significant benefits for treating B-cell lymphoma and various autoimmune diseases, but its effects are limited in central nervous system (CNS) disorders due to the blood-brain barrier.
- Multiple sclerosis (MS), particularly its progressive phase, is a key CNS autoimmune disorder that resists existing treatments, highlighting the potential of intrathecal (IT) therapies to deliver drugs directly to the affected area.
- The review discusses findings from animal studies and human cases using intrathecal rituximab for CNS lymphomas and emphasizes the need for clinical trials on its use in multiple sclerosis, providing foundational data for future CNS autoimmune research.
We report 2 patients with ischemic stroke related to an initial severe focal narrowed middle cerebral artery caused by a dissection mechanism, a presentation that has received little attention to date. Diagnostic modalities and follow-up using transcranial color-coded sonography are reported and discussed. Results with transcranial color-coded sonography were correlated with computed tomographic angiography, showing the great value of this radiation-free arterial monitoring process in this setting, especially in young adults.
View Article and Find Full Text PDFObjective: A significant advancement in the management of acute ischemic stroke has been the use of the recombinant tissue plasminogen activator (rtPA). French guidelines recommend that stroke patients should be treated in stroke units (SU); however, community hospitals experience practical difficulties in treating their patients because SUs are not sufficient in number. Only one SU is available in the Aquitaine area (southwest of France) and it is located in Bordeaux.
View Article and Find Full Text PDFArticle Synopsis
- Acute hemiplegia with headaches can be caused by nonvascular issues, not just strokes.
- Two case studies illustrate this: one patient had sporadic hemiplegic migraines, while the other showed transient symptoms with headaches and neurological deficits.
- The findings highlight the challenge of diagnosing acute motor weakness and emphasize the need to consider nonvascular causes to avoid misdiagnosis and incorrect treatment.