Publications by authors named "Eric Benzenine"
Article Synopsis
- * Parkinson's disease (PD) patients treated with l-DOPA show some protection against nAMD, but the exact mechanism was unclear until now.
- * Research indicates that l-DOPA enhances dopamine receptor D2 (DRD2) signaling, which may inhibit the harmful growth of blood vessels in the eye, suggesting that DRD2 agonists could be potential complementary treatments for nAMD.
Aim: The association between infection with SARS-CoV-2 and the development of new-onset type 1 diabetes mellitus (T1DM) is unclear. The aim of this study was to examine the impact of the Covid-19 pandemic on the hospitalization rates for new-onset T1DM and diabetic ketoacidosis at diagnosis, in metropolitan France.
Methods: This nationwide retrospective cohort study included hospital data on all patients aged 1 to 35 years old, hospitalized in France due to onset of T1DM, in 2020 and 2021 compared to 2019.
Article Synopsis
- The study investigates the role of topical antibiotic prophylaxis in preventing acute endophthalmitis after intravitreal injections (IVTs), analyzing data from over 5 million injections in France from 2009 to 2018.
- Findings reveal a significant decrease in the use of prophylactic antibiotics over time, with 1274 cases of endophthalmitis reported (an incidence rate of 0.0241%).
- The study concludes that antibiotic prophylaxis does not effectively lower the risk of endophthalmitis, and in fact, using certain combinations of antibiotics with corticosteroids may increase that risk, suggesting that avoiding such prophylaxis could reduce costs and mitigate antibiotic resistance concerns.
Article Synopsis
- - The COVID-19 pandemic caused a significant decline in hospitalizations for myocardial infarction (MI) and stroke just before the nationwide lockdown in France, dropping by 36.5% for MI and 31.2% for stroke.
- - Hospitalization rates returned to pre-pandemic levels four weeks after the lockdown ended, but MI hospitalizations rebounded excessively compared to 2019.
- - COVID-19 patients were characterized by older age, male sex, and higher rates of hypertension, diabetes, and obesity, but there were no changes in the spatial distribution of hospitalizations over the analyzed periods.
Article Synopsis
- A nationwide cohort study in France examined the use of intravitreal injections (IVTs) of anti-VEGF agents and corticosteroids in pregnant women, focusing on obstetric and neonatal complications.
- From 2009 to 2018, only 228 IVTs were given to 139 pregnant women out of over 5.6 million total IVTs performed in the country.
- The study found a high incidence of obstetric complications among those receiving anti-VEGF (16.1% had spontaneous abortion or termination) compared to corticosteroids (3.1%), but no statistically significant link was established between the injections and these complications, highlighting the need for caution in their use during pregnancy.
Purpose: To report the incidence of postoperative rhegmatogenous retinal detachment after macular surgery in France between 2006 and 2016, and identify associated factors.
Design: Nationwide, population-based, cohort study.
Methods: All surgical procedures for an epiretinal membrane or a macular hole performed in France from January 1, 2006 to October 31, 2016 were identified in the French national administrative database (Programme de Médicalisation des Systèmes d'Information).
Article Synopsis
- The study investigates the effects of the COVID-19 pandemic on hospitalizations for myocarditis and endocarditis in France, comparing data before, during, and after the lockdown.
- Results show a rise in myocarditis cases by 11% and endocarditis cases by 7% in 2020 compared to previous years, with a significant portion associated with COVID-19.
- The study highlights that patients with COVID-19 had higher rates of risk factors like obesity and diabetes for myocarditis, indicating a need for targeted monitoring and treatment for at-risk individuals.
Article Synopsis
- The study aimed to identify the causes of postoperative acute endophthalmitis in France from 2009 to 2018, examining 7522 cases following over 14 million intraocular procedures.
- Most cases were related to standalone cataract surgeries, while intravitreal injections and vitreoretinal surgeries also contributed significantly.
- The overall incidence of acute endophthalmitis was low, at 0.0521%, with scleral and globe surgeries having the highest incidence among the various procedures.
Article Synopsis
- The study examined how the COVID-19 pandemic affected carotid revascularization procedures (CEA and TFCAS) for patients in France before, during, and after the first lockdown in 2020.
- Data from the French National Hospital Discharge database revealed a significant drop in hospitalizations for both asymptomatic (down 68.9%) and symptomatic (down 12.6%) procedures during peak lockdown in April 2020.
- Post-lockdown, there was a rebound in procedures for symptomatic stenosis, while asymptomatic CEA rates returned to normal, indicating varying impacts of the pandemic on different types of surgeries.
Article Synopsis
- The study investigates the impact of the COVID-19 lockdown on hospitalizations for cardiovascular emergencies in France, comparing data from before, during, and after the lockdown.
- A significant overall decline in hospitalizations for critical conditions was observed during the lockdown period, except for an increase in circulatory assistance cases.
- Post-lockdown, there was a slight increase in certain emergency cases like mechanical complications of myocardial infarction and aortic aneurysm ruptures, indicating some patients gained access to necessary surgical care after restrictions eased.
Background/aims: The COVID-19 crisis and the decisions made regarding population lockdown may have changed patient care. We aimed to investigate the incidence rate of rhegmatogenous retinal detachment (RRD) cases during the COVID-19 lockdown period.
Methods: In this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France from 2017 to the lockdown period in 2020.
Article Synopsis
- This study investigates the impact of noise on the relationship between fetal growth restriction (FGR) or small for gestational age (SGA) in single pregnancies and exposure to air pollution in two French cities between 2005 and 2009.
- Researchers analyzed data from 8,994 pregnancies, identifying 587 cases of FGR and 918 cases of SGA, while measuring outdoor air pollution (nitrogen dioxide and particulate matter) and noise levels at mothers' residences.
- Findings indicate a significant association between increased particulate matter exposure and fetal growth issues, specifically during the late stages of pregnancy, while noise exposure showed no connection to FGR or SGA.
Article Synopsis
- The study aimed to investigate how the COVID-19 pandemic affected hospitalization rates for diabetic foot ulcers (DFU), osteomyelitis, and related procedures in France.
- Researchers analyzed hospital data from the lockdown phase of 2020, comparing it to the same timeframe in 2019.
- Findings showed a significant decrease in hospitalizations for DFU, osteomyelitis, and lower limb surgeries during lockdown, indicating that COVID-19 negatively impacted care for these conditions.
Aims: To investigate the annual and monthly hospital incidence rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 2016 in France at the national and regional levels.
Methods: In this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France during 2010-2016 from the national administrative database. The annual and monthly hospital incidence rates of RRD per 100 000 population were calculated for the whole country and for each region.
Background And Purpose: In France, the entire population was put under a total lockdown from March 17 to May 11, 2020 during the peak of the coronavirus disease 2019 (COVID-19) pandemic. Whether the lockdown had consequences on the management of medical emergencies such as stroke and transient ischemic attack (TIA) has yet to be fully evaluated. This article describes hospitalization rates for acute stroke in 2 French regions that experienced contrasting rates of COVID-19 infection, before, during, and after the nationwide lockdown (January to June 2020).
View Article and Find Full Text PDFEvaluation of the Quality of French Hospital Data for Perinatal Algorithms.
Stud Health Technol Inform
June 2020
The aim of our validation study was to assess the quality of hospital data for perinatal algorithms on a national level. In each hospital, we selected 150 discharge abstracts of delivery (after 22 weeks of gestation), in 2014, and their corresponding medical records. Overall, 23 hospitals were included and 3,246 discharge abstracts were studied.
View Article and Find Full Text PDFBackground: Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to evaluate the impact of VTE and major bleeding on survival and to identify significant risk factors for these events in lung cancer patients.
View Article and Find Full Text PDFObjective: The aim of our validation study was to assess the metrological quality of hospital data for perinatal algorithms on a national level.
Design: Validation study.
Setting: This was a multicentre study of the French medicoadministrative database on perinatal indicators.
Venous thromboembolism is highly prevalent in lung cancer patients. Low molecular weight heparins are recommended for long term treatment of cancer associated venous thromboembolism. Direct oral anticoagulants are however an interesting alternative as they are administered orally and don't require monitoring.
View Article and Find Full Text PDFPurpose: To report the incidence of acute postoperative endophthalmitis (POE) after macular surgery in France between 2006 and 2016 and to identify associated factors.
Methods: This retrospective database study included all hospital discharge records involving a surgical procedure for an epiretinal membrane or a macular hole in France from January 2006 to October 2016. Acute POE was identified by two codes in the tenth edition of the International Classification of Diseases within 42 days of a macular surgical procedure in the French national administrative database.
Background: Children born to mothers with IBD may be exposed to anti-TNFα agents antenatally. Current European guidelines recommend postponing live vaccines until after 6 months of life in this population. Data on the safety of live vaccines administration in the first year of life of these children are sparse with one reported fatality following bacillus Calmette-Guerin (BCG) administration.
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- This study focuses on the effects of air pollution, specifically nitrogen dioxide (NO), on fetal growth in women with multiple pregnancies, which are often excluded from such research.
- Conducted in Besançon and Dijon between 2005 and 2009, it examined medical records and assessed NO exposure based on residential addresses during key pregnancy periods.
- Results showed no link between NO and small for gestational age infants, but indicated a potential association between higher NO exposure and fetal growth restriction, highlighting the need for further investigation even at pollution levels below EU standards.
Importance: The number of patients affected by retinal diseases treated with intravitreal injections (IVTs) has resulted in a rapidly growing number of procedures. One of the worst complications after these injections is endophthalmitis.
Objective: To evaluate the incidence of acute endophthalmitis after IVTs of corticosteroids or anti-vascular endothelial growth factor (anti-VEGF) agents.
Objectives: Inflammatory bowel diseases (IBD) need long-term treatment, which can influence pregnancies in young women. Uncontrolled IBD is associated with poor pregnancy outcomes. Despite the labeling of Anti-tumor necrosis factor (TNF) antibodies (anti-TNFα) which indicates that their use is not recommended during pregnancy, anti-TNFα are increasingly being used during pregnancy and may expose women and their fetuses to treatment-related complications.
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