Nanodiamond-Enabled Thin-Film Nanocomposite Polyamide Membranes for High-Temperature Water Treatment.

Despite growing demands for high-temperature wastewater treatment, most available polymeric membranes are limited to mild operating temperatures (<50 °C) and become less efficient at high temperatures. Herein we show how to make thermally stable reverse osmosis thin-film nanocomposite (TFN) membranes by embedding nanodiamond (ND) particles. Polyamide composite layers containing different loadings of surface-modified ND particles were synthesized through interfacial polymerization.

Potent triazolyl-proline-based inhibitors of HCV NS3 protease.

The design and synthesis of tripeptide-based inhibitors of the HCV NS3 protease containing a novel P2-triazole is described. Replacement of the P2 quinoline with a triazole moiety provided a versatile handle which could be expediently modified to generate a diverse series of inhibitors. Further refinement by the incorporation of an aryl-substituted triazole and replacement of the P1 acid with an acyl sulfonamide ultimately provided inhibitors with interesting cellular activity.