Publications by authors named "Eric Bauza"
Article Synopsis
- The project aimed to create a 3D reconstructed human cornea-like epithelium (RhCE) for early-stage product screening of liquid chemicals regarding eye safety.
- Histological analyses showed that the RhCE model, made with Normal Human Keratinocytes, has a well-organized structure and effective barrier functionality, making it suitable for testing.
- The model demonstrated high prediction accuracy (84.4%) and reliability in classifying chemicals based on their eye damage potential, indicating it could serve as a useful tool for eye hazard identification.
In recent years, in vitro skin models combining cell biology and tissue engineering have been developed in order to replace animal models for toxicological studies and to serve as research support to better understand skin biology. This study reports the development and characterization of a epidermal tissue equivalent meant to be used to develop and to evaluate the effect of applied cosmetic ingredients, and for alternative toxicological testing. This epidermis equivalent model was characterized relative to the morphological characteristics of short- and long-term maintained tissues by performing histological studies.
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