Publications by authors named "Eric Arezza"
Article Synopsis
- Caspase activated DNase (CAD) causes DNA breaks that play a role in both cell differentiation and cancer cell resistance, revealing a complex relationship between these processes.
- Researchers discovered that certain CAD-targeted genes in muscle cells, like Pax7 and Foxo1a, are also implicated in cancer-related genetic alterations, particularly in alveolar rhabdomyosarcoma.
- The findings indicate that the DNA breaks induced by CAD in these genes are a natural part of muscle cell differentiation, connecting the dots between normal cellular transitions and cancer development.
SMCHD1 is an epigenetic regulatory protein known to modulate the targeted repression of large chromatin domains. Diminished SMCHD1 function in muscle fibers causes Facioscapulohumeral Muscular Dystrophy (FSHD2) through derepression of the D4Z4 chromatin domain, an event which permits the aberrant expression of the disease-causing gene DUX4. Given that SMCHD1 plays a broader role in establishing the cellular epigenome, we examined whether loss of SMCHD1 function might affect muscle homeostasis through additional mechanisms.
View Article and Find Full Text PDFThe soybean cyst nematode (SCN) [ Ichinohe] is a devastating pathogen of soybean [ (L.) Merr.] that is rapidly becoming a global economic issue.
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