The role of Hippophae rhamnoides L. on 5-fluorouracil-ınduced oral mucositis in rats.

Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). The 5-FU was injected in the FUG group intraperitoneally.

Protective effect of lutein against acrolein-induced ototoxicity in rats.

Background: Acrolein is a reactive aldehyde that forms during burning of wood and other fuels. It is also a product of lipid peroxidation (LPO) reactions and is present in cigarette smoke. Acrolein is known to cause oxidative stress and inflammatory nerve tissue damage.

Mismatch-tolerant, alignment-free sequence classification using multiple spaced seeds and multiindex Bloom filters.

Alignment-free classification tools have enabled high-throughput processing of sequencing data in many bioinformatics analysis pipelines primarily due to their computational efficiency. Originally -mer based, such tools often lack sensitivity when faced with sequencing errors and polymorphisms. In response, some tools have been augmented with spaced seeds, which are capable of tolerating mismatches.

Thermodynamically designed target-specific DNA probe as an electrochemical hybridization biosensor.

Applications of molecular techniques to elucidate identity or function using biomarkers still remain highly empirical and biosensors are no exception. In the present study, target-specific oligonucleotide probes for E. coli K12 were designed thermodynamically and applied in an electrochemical DNA biosensor setup.

Radiofrequency thermocoagulation combined with pulsed radiofrequency for gasserian ganglion blockage.

Objectives: Trigeminal neuralgia (TN) has been effectively treated by radiofrequency thermocoagulation (RFT) of the gasserian ganglion. Recently, pulsed radiofrequency (PRF) is becoming an alternative therapy for patients with trigeminal neuralgia. It is unclear whether the combination of RFT with PRF may decrease post-operative complications while maintaining longterm pain relief.

Alignment-free clustering of UMI tagged DNA molecules.

Motivation: Next-Generation Sequencing has led to the availability of massive genomic datasets whose processing raises many challenges, including the handling of sequencing errors. This is especially pertinent in cancer genomics, e.g.

The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate.

Objective:: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX.

Material And Methods:: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day.

Effect of Extract on Oxidative Oropharyngeal Mucosal Damage Induced in Rats Using Methotrexate.

Objectives: The objective of this study is to investigate and evaluate the effect of extract (HRE) on oropharyngeal mucositis induced in rats with methotrexate (MTX) through biochemical, gene expression, and histopathological examinations.

Methods: Experimental animals were divided into a healthy group (HG), a HRE+MTX (HREM) group, HRE group (HREG), and a control group that received MTX (MTXG). The HREM and HREG groups of rats was administered 50 mg/kg HRE, while the MTXG and HG groups were given an equal volume distilled water with gavage.

Development and operation of gold and cobalt oxide nanoparticles containing polypropylene based enzymatic fuel cell for renewable fuels.

Newly synthesized gold and cobalt oxide nanoparticle embedded Polypropylene-g-Polyethylene glycol was used for a compartment-less enzymatic fuel cell. Glucose oxidase and bilirubin oxidase were selected as anodic and cathodic enzymes, respectively. Electrode fabrication and EFC operation parameters were optimized to achieve high power output.

Paintball-related ocular trauma: Paintball or Painball?

Background: The aim of this study is to describe the type and severity of paintball-related ocular trauma and to determine the necessary precautions to minimize the risk of ocular injury regardless of whether adequate eye protection was used.

Material And Methods: A retrospective chart review identified patients treated for paintball-related ocular trauma at the Ataturk University Medical Hospital from June 2010 through March 2013. A descriptive analysis of data was performed.

Biological NOx removal by denitrification process in a jet-loop bioreactor: system performance and model development.

Nitrogen monoxide (NO) and nitrogen dioxide referred as NOx are one of the most important air pollutants in the atmosphere. Biological NOx removal technologies have been developing to reach a cost-effective control method for upcoming stringent NOx emission standards. The BioDeNOx system was seen as a promising biological NOx control technology which is composed of two reactors, one for absorbing of NO in an aqueous Fe(II)EDTA2- solution and the other for subsequent reduction to N2 gas in a biological reactor by the denitrification process.

The effect of head rotation on intraocular pressure in prone position: a randomized trial.

Background And Objectives: The increased intraocular pressure (IOP) - which decreases perfusion pressure on the optic nerve - increases by prone positioning (1). The aim of our study was to compare the effect of head rotation 45° laterally in prone position on the increase in IOP of upper placed and lower placed eyes in patients undergoing percutaneous nephrolithotomy (PCNL).

Methods: Forty-five patients were randomly divided into 2 Groups.

Evaluation of a Multimodal Approach to Postoperative Pain in Patients Undergoing Flank Incision in the Urology Operating Room.

Objective: In this study, we evaluated subcutaneous (sc) morphine in combination with multimodal analgesia for postoperative pain control after radical nephrectomy and pyeloplasty with flank incision.

Methods: Forty-nine patients under The American Society of Anesthesiologists Physical Status classification (ASA) I-III aged 18-85 years undergoing radical nephrectomy and pyeloplasty with flank incision were included in this prospective, randomised study. The patients were divided into two groups (Group O [n=25] and Group M [n=24]) and received standard general anaesthesia.

Comparison of 75 and 150 μg doses of intrathecal morphine for postoperative analgesia after transurethral resection of the prostate under spinal anesthesia.

Objective: The administration of single dose intrathecal (IT) morphine with local anesthetics during spinal anesthesia produces an effective postoperative analgesia. In this study, we evaluated the efficacy and safety of two different doses of IT morphine with bupivacaine for postoperative analgesia after transurethral resection of prostate (TURP).

Study Design: Prospective, randomized study.

Anesthetic technique in a patient with multiple sclerosis scheduled for laparoscopic nephrectomy for a renal tumor: a case report.

Perioperative stress and anesthesia are risk factors for exacerbation of Multiple Sclerosis (MS) attacks. Infection, emotional labiality and hyperpyrexia are also known to increase the risk of postoperative MS attacks. Appropriate preoperative evaluation, administration of a good premedication, control of fever, selection of the anesthetic agents and effective postoperative pain control can prevent problems after prolonged major surgery in patients with MS diagnosed.

The Effect of EMLA Cream on Patient-Controlled Analgesia with Remifentanil in ESWL Procedure: A Placebo-Controlled Randomized Study.

Background: To alleviate stinging pain in the skin entry area and visceral discomfort in patients who are undergoing ESWL.

Objectives: This study was designed to investigate the effectiveness of the EMLA cream in combination with remifentanil patient-controlled analgesia (PCA) in patients undergoing ESWL treatment.

Patients And Methods: Sixty patients were divided into two double-blind randomized groups.

The effect of preoperative intravenous dexketoprofen trometamol on postoperative pain in minor outpatient urologic surgery.

Objective: The aim of this prospective double-blind randomized study was to compare the effectiveness of preoperative dexketoprofen trometamol for acute postoperative pain in patients undergoing minor outpatient urologic surgery.

Material And Methods: Sixty male patients (ASA I and II) undergoing varicocelectomy and testicular sperm extraction (TESE) with standard laryngeal mask airway (LMA) anesthesia were randomly divided into two groups. Patients in Group I (n=30) received 50 mg of dexketoprofen trometamol iv before induction, whereas patients in Group II (n=30) received saline.

Intrathecal morphine reduces postoperative tramadol consumption in patients undergoing radical retropubic prostatectomy: a randomized trial.

Background: Intrathecal (IT) morphine provides prolonged analgesia after major surgery.

Aim: The aim of our study was to assess the impact of intrathecal morphine 200 µg on patient-controlled analgesia (PCA) tramadol consumptions and postoperative pain in patients who underwent radical retropubic prostatectomy (RRP) under general anesthesia.

Materials And Methods: In this prospective trial, 56 men who underwent radical retropubic prostatectomy (RRP) were randomized into 2 groups.

The effect of head rotation on intraocular pressure in prone position: a randomized trial.

Background And Objectives: The increased intraocular pressure (IOP) - which decreases perfusion pressure on the optic nerve - increases by prone positioning (1). The aim of our study was to compare the effect of head rotation 45° laterally in prone position on the increase in IOP of upper placed and lower placed eyes in patients undergoing percutaneous nephrolithotomy (PCNL).

Methods: Forty-five patients were randomly divided into 2 Groups.

Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy.

Objective: The impact of preoperative gabapentin on tramadol consumption using patient-controlled analgesia (PCA) and postoperative pain was assessed in patients undergoing radical retropubic prostatectomy (RRP).

Methods: In this prospective, randomized trial, 51 patients undergoing RRP were randomized into two groups: the gabapentin group received 900 mg gabapentin orally 2 h before surgery; the control group did not receive gabapentin. Postoperative analgesia was provided by tramadol PCA.

Amperometric nitrate biosensor based on Carbon nanotube/Polypyrrole/Nitrate reductase biofilm electrode.

This study describes the construction and characterization of an amperometric nitrate biosensor based on the Polypyrrole (PPy)/Carbon nanotubes (CNTs) film. Nitrate reductase (NR) was both entrapped into the growing PPy film and chemically immobilized via the carboxyl groups of CNTs to the CNT/PPy film electrode. The optimum amperometric response for nitrate was obtained in 0.

Efficiency of antibiotic-loaded polymethylmethacrylate rods for treatment of the implant-related infections in rat spine.

Study Design: A study of local treatment of the implant-related infections in animal spine.

Objective: : This study aims to investigate the efficiency of antibiotic-loaded polymethylmethacrylate rods for treatment of the implant-related infections.

Summary Of Background Data: Today's implant-related vertebral infections are challenging in spinal surgery.

Newly synthesized poly(glycidyl methacrylate-co-3-thienylmethylmethacrylate)-based electrode designs for phenol biosensors.

A newly synthesized poly(glycidyl methacrylate-co-3-thienylmethylmethacrylate) [poly(GMA-co-MTM)] was designed to fabricate various HRP electrodes for detection of phenol derivatives. The results showed that the poly(GMA-co-MTM)/polypyrrole composite film microarchitecture provided a good electroactivity as a result of pyrrole and thiophene interaction, and provided chemical bonds for enzyme immobilization via the epoxy groups of poly(GMA-co-MTM). The glassy carbon-based working electrode displayed significantly higher performance for the same composite film configuration comparing to the gold-based working electrode.

Thermostable amperometric lactate biosensor with Clostridium thermocellum L-LDH for the measurement of blood lactate.

The gene for Clostridium thermocellum L-lactate dehydrogenase enzyme was cloned into pGEX-4T-2 purification vector to supply a source for a thermostable enzyme in order to produce a stable lactate biosensor working at relatively high temperatures. The purified thermostable enzyme (t-LDH) was then immobilized on a gold electrode via polymerization of polygluteraldehyde and pyrrol resulting in a conductive co-polymer. t-LDH working electrode (t-LDHE) was used for determination of lactate in CHES buffer.