Publications by authors named "Erfeng Xiong"
Ischemia-reperfusion injury (IRI) is the leading cause of hepatic graft dysfunction, resulting from hepatocyte damage. Nevertheless, given the few specialized therapeutics available in hepatic IRI, additional mechanistic insights into hepatocyte damage are required. Here, the protein solute carrier family 39 member 14 (SLC39A14) is identified as a pro-ferroptosis target in hepatocytes of human liver allografts through single-cell RNA sequencing analysis.
View Article and Find Full Text PDFBackground: Self-efficacy, as the vital determinant of behavior, influencing clinicians' situation awareness, work performance, and medical decision-making, might affect the incidence of anesthesia-related adverse events (ARAEs). This study was employed to evaluate the association between perceived self-efficacy level and ARAEs.
Methods: A cross-sectional study was performed in the form of an online self-completion questionnaire-based survey.
Article Synopsis
- * A total of 160 subjects participated in pain threshold experiments while their COMT gene variants and β-endorphin levels were measured.
- * Results showed significant differences in pain sensitivity between the two ethnic groups, with specific genetic variants and low β-endorphin levels linked to lower pain thresholds, particularly in young, female, and Uyghur participants.
Article Synopsis
- Gene-environment interaction plays a significant role in determining preoperative anxiety, with ABO blood types serving as a genetic factor influencing this anxiety.
- A study involving 352 patients revealed that those with AB blood types exhibited higher levels of anxiety compared to those with other blood types, as measured by the Hospital Anxiety and Depression Scale (HADS) and Visual Analogue Scales (VAS).
- Results indicated that factors such as gender, ASA grade, and pain levels also correlated with preoperative anxiety, highlighting the complexity of anxiety's causes beyond just genetic factors.
Aim: Endoplasmic reticulum stress (ERS) is vital in inducing apoptosis via caspase-12 and C/EBP homologous protein (CHOP) apoptotic pathway in the hippocampus after ischemia-reperfusion injury. The study aimed to estimate the efficacy of estrogen and propofol combination therapy against ERS-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (OGD) injury in the hippocampus in vivo and in vitro.
Methods: Rat model of cerebral ischemia-reperfusion injury was generated by middle cerebral artery occlusion (MCAO) strategy with ischemic intervention for 90 min and reperfusion for 24 h.