Publications by authors named "Erfan Pari"
Mol Biol Rep
January 2024
Article Synopsis
- Methylphenidate (MPH) abuse may lead to neurodegeneration and increased seizure risks, while topiramate (TPM), an antiepileptic drug, shows promise as a neuroprotective agent against these complications when delivered via nanoparticles.
- The study employed male rats divided into groups receiving MPH and varying doses of TPM and mesoporous silica nanoparticles (MSN) with zinc or copper cores over three weeks, followed by seizure induction to assess neuroprotective effects.
- Results indicated that TPM-loaded nanoparticles significantly improved seizure latency and duration, reduced inflammatory markers and oxidative stress in the hippocampus, suggesting their potential as protective agents against MPH-induced neurotoxicity.
