Objectives: A comparative dissolution kinetics test (CDKT) and bioequivalence studies of generic proton pump inhibitors (PPIs) do not model pharmacological acid suppression (PAS) and pathological duodenogastric reflux (PDGR). This study aimed to model them in CDKT to assess drugs stability and potential pantoprazole-clarithromycin interactions.
Methods: In CDKT, PDGR (dissolution medium pH 7.
Vestn Otorinolaringol
July 2021
Pharmacotherapy for allergic rhinitis is based on different categories of drugs used either in monotherapy or in combination regimens. The current clinical guidelines suggest a stepwise approach to pharmacotherapy for allergic rhinitis. The use of intranasal corticosteroids is considered as the preferred second-stage pharmacotherapy.
View Article and Find Full Text PDFBackground High values of endogenous levels of magnesium (Mg) in the body and mechanisms of homeostasis regulation make it difficult to assess the bioavailability of these drugs. The aim of this study was to assess the Mg concentration in blood in volunteers and in erythrocytes in patients with hypomagnesemia. Methods The study included 20 healthy volunteers and 62 patients with chronic heart failure (CHF) I-III functional class (FC) NYHA classification.
View Article and Find Full Text PDFDrug Metab Pers Ther
September 2018
Some inflammatory cytokines and parameters of low density lipoproteins (LDL) oxidative modification were studied in blood of 250 acute coronary syndrome (ACS) patients--Siberian inhabitants, men and women with myocardial infarction (MI) or unstable angina on first, tenth and thirtieth days of disease. The inflammatory biomarkers in men and women with MI are: increased concentrations of interleukin (IL)-6, IL-8 and C-reactive protein (CRP), especially on the first day of disease. The most significant inflammatory biomarker of ACS is increased CRP level, especially in women.
View Article and Find Full Text PDFBlood levels of stem cell marker proteins CD34 and osteonectin were studied in male patients with coronary atherosclerosis by direct biomagnetic separation of proteins with magnetic microspheres using the PureProteome Protein A and Protein G Magnetic Beads proteomic technology. High concentration of osteonectin in the blood was detected, particularly in men with stenosing atherosclerosis and coronary artery calcinosis. Blood osteonectin concentration correlated significantly with some key biomarkers of atherosclerosis and with stenosing atherosclerosis and calcinosis of coronary arteries.
View Article and Find Full Text PDFLaboratory lipid and lipoprotein biomarkers (total cholesterol - CH, triglycerides - TG, low-density and high-density lipoprotein cholesterol- LDL-CH, HDL-CH, apolipoproteins B and A1 - apoB, apoA1), carbohydrate biomarkers (plasma glucose, basal insulin), high sensitive C-reactive protein (hsCRP) and oxidative biomarkers (basal level of lipid peroxidation [LPO] products in LDL, LDL resistance to oxidation in vitro, oxidative modification of apoLDL and level of LDL lipophilic antioxidants) were studied in 388 men aged 42-70 years: 96 citizens of Western Siberia with angiographically documented coronary atherosclerosis and coronary heart disease (CHD); 292 men of population sample of citizens of Novosibirsk, including 44 men with CHD confirmed by standardized criteria and methods. Significant associations were found of coronary atherosclerosis and CHD with laboratory diagnostic biomarkers like blood levels of HDL-CH, TG, apoB, apoA1, basal insulin, hsCRP and basal level of LPO products in LDL and LDL resistance to oxidation.
View Article and Find Full Text PDFThis study has demonstrated that the treatment of patients with grade II-III arterial hypertension using fixed combinations of corinetec and gyzaar supplemented by acupuncture reflexotherapy resulted in a significantly more pronounced decrease of daily monitored arterial pressure than in patients who received the drug therapy without acupuncture.
View Article and Find Full Text PDFZh Mikrobiol Epidemiol Immunobiol
August 2006
Components of the capsule antigen (Baker), described early as F17, F18, F43, Flp, which positively reacts with commercial poly- and monoclonal antifractions plague diagnosticums were studied. Differences and their impacts on vaccine bacteria survival within peritoneal macrophages, guinea pigs and protection of white mice after immunization and fast protection against plague were shown. Hemolytic, cytolytic and hemo- and cytoagglutinations activities of lipoprotein (Flp) and capacity of glycoproteins F17 and F43 for induction of hemo- and cytoagglutinations were detected.
View Article and Find Full Text PDFZh Mikrobiol Epidemiol Immunobiol
May 2006
The F1-specific components of Y. pestis capsular antigen, isolated by Baker's method, were shown to differ by their biological activity and the character of action on cell-mediated immunity factors, used in this study. Depending on the method of isolation, antigens could vary in the proportion of their components, which determined the specific features of the total preparations obtained in this investigation.
View Article and Find Full Text PDFMol Gen Mikrobiol Virusol
May 2003
Wild-type strains of plague agent Yersinia pestis are characterized by a pigmentation phenotype (Pgm+), which includes several traits: an ability of cells to adsorb pigments (Hms+), an ability to produce siderophore yersiniabactin (Ybt+) and an ability to cause lethal infections in laboratory animals (Vir+) after subcutaneous injections. All these traits are encoded in the chromosomal pgm-locus, which gets rapidly lost due to deletion. One more trait related with the Pgm+ phenotype was detected in the present study, i.
View Article and Find Full Text PDFMol Gen Mikrobiol Virusol
October 2002
Yersinia pestis vaccine strain EV76 is a mutant of the virulent strain which has lost the pigmentation phenotype (Pgm+). This phenotype includes three characteristics: it absorbs pigments from agar media (Hms+), produces a siderophore yersiniabactin (Ybt+), and causes a lethal disease after subcutaneous inoculation of laboratory animals (Vir+). These characteristics are lost simultaneously after high frequency spontaneous deletion of 10 kB fragment of chromosomal DNA, termed the pgm locus.
View Article and Find Full Text PDFThe paper analyses results after investigation of free selection of families, parents myopia selected by signs and a definite minimum age of their first-order offsprings, including 108 matrimonial couples with the total number of 209 children. It was found that myopia is a hereditary sign manifesting itself in children at the age above 15 years and more in 90% of families of the first-order offsprings of the couples in whom one of the parents has this kind of refraction, and in 100% of families in whom both parents suffer from this kind of refraction. The incidence of myopic children in families in whom one or both parents have myopia ranges from 68% to 86%, and depends on the type of refraction.
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