Publications by authors named "Erdogan Tastan"
J Chem Inf Model
August 2012
Article Synopsis
- The study introduces a new computer-based protocol for predicting how mutations affect protein binding by simulating conformational changes and calculating free energy variations.
- The protocol was tested on 173 mutations across 7 protein complexes, revealing that combining two prediction methods led to identifying mutations that enhanced binding, with a success rate of 45%.
- For more complex mutations requiring multiple base changes, the success rate rose to 63%, and the protocol successfully detected 89% of significant mutation hotspots in 56 alanine scanning tests.
