Publications by authors named "Erdem Basaran"
Article Synopsis
- The study analyzes data from the CF Registry of Turkey to measure the rate of decline in pulmonary function (ppFEV1) among cystic fibrosis patients and identifies risk factors related to this decline.
- It found that patients with more severe disease (ppFEV1 < 40) had poorer nutritional status and a higher prevalence of chronic Pseudomonas aeruginosa infection compared to those with better lung function.
- The results emphasize the need for regular monitoring of patients with normal initial ppFEV1 and early treatment for P. aeruginosa infections, highlighting the crucial role of proper nutrition in managing cystic fibrosis.
Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs target the underlying defect and improve CFTR function. They are a part of standard care in many countries, but not all patients are eligible for these drugs due to age and genotype. Here, we aimed to determine the characteristics of non-eligible patients for CFTR modulators in the CF registry of Turkey (CFRT) to highlight their clinical needs.
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- Cystic fibrosis (CF) is a genetic disease that can make it hard for people to breathe, and some medicines called CFTR modulators can help them feel better.
- This study looked at CF patients in Turkey who needed these medicines but couldn't get them in 2018 and 2019.
- After a year, the patients who missed out on treatment got worse, having more issues with their lungs and needing extra help to breathe and eat.
Background: We aimed to determine the number of cystic fibrosis (CF) patients recorded in the Cystic Fibrosis Registry of Türkiye (CFRT) who were in need of lung transplantation (LT) referral and examine clinical differences between patients who were LT candidates due to rapid forced expiratory volume in one second (FEV₁) decline and LT candidates without rapid FEV₁ decline in the last year to identify a preventable cause in patients with such rapid FEV₁ decline.
Methods: All CF patients recorded in the CFRT in 2018 were evaluated in terms of LT. Patients were divided into those with FEV₁ below 50% and in need of LT due to a decrease of 20% or more in the previous year (Group 1) and those who did not have FEV₁ decline of more than 20% in the previous year but had other indications for LT (Group 2).
Objective: (s): We aimed to investigate the effects of mesenchymal stem cell secretome and methysergide combination on 5-hydroxytryptamine 2A, (5-HT2AR), 5-hydroxytryptamine 7 (5-HT7R), adenosine 2A (A2AR) receptors and CD73 on neuroblastoma cell line and how they affect biological characteristics. Methysergide was used as a serotonin antagonist on the neuroblastoma cells.
Materials And Methods: Human dental pulp-derived stem cells (hDPSCs) used to obtain conditioned medium (CM).
Objectives: To determine the demographic, clinical, and genetic profile of Turkish Caucasian PCD cases.
Methods: Targeted next-generation sequencing (t-NGS) of 46 nuclear genes was performed in 21 unrelated PCD cases. Sanger sequencing confirmed of potentially disease-related variations, and genotype-phenotype correlations were evaluated.
Article Synopsis
- FCHO1 deficiency is a newly identified genetic condition that results in a combined immune deficiency.
- It is inherited in an autosomal recessive manner, meaning that both parents must carry the gene for a child to be affected.
- The condition is linked to problems with clathrin-mediated endocytosis, a process essential for cells to take in nutrients and signaling molecules.